Advertisement

Brain-Tumor Related Epilepsy

  • Efthimios Dardiotis
  • Maria Sokratous
  • Katerina Markou
  • Georgios M. Hadjigeorgiou
Chapter

Abstract

Brain tumor related epilepsies (BTREs) account for about 12% of all acquired epilepsies and are a common symptom of brain tumors. The clinical signs and symptoms vary and are mainly focal in onset or secondarily generalized. Their features are indicative of their origin in the region of the brain. BTREs are difficult to manage because they usually are drug-resistant. The patients’ characteristics should be carefully evaluated in selecting the appropriate antiepileptic drug (AED) and the therapeutic scheme.

Keywords

Partial seizures Generalized seizures Temporal lobe epilepsy Automatisms Glioma Antiepileptic drug Electroencephalogram 

References

  1. 1.
    Salmaggi A, Granata T, Rigamonti A. Pathophysiology of brain tumor-related epilepsy. In: Newton HB, Maschio M, editors. Epilepsy and brain tumors. Boston: Academic; 2015. p. 111–8.CrossRefGoogle Scholar
  2. 2.
    van Breemen MS, Wilms EB, Vecht CJ. Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management. Lancet Neurol. 2007;6:421–30.CrossRefGoogle Scholar
  3. 3.
    Rudzinski LA, Shih JJ. The classification of seizures and epilepsy syndromes. Continuum (Minneapolis, MN). 2010;16:15–35.Google Scholar
  4. 4.
    Rogers L. Cancer and the nervous system clinical features and complications. In: Daroff RB, Jankovics J, Mazziotta JC, Pomeroy SL, editors. Bradley's neurology in clinical practice. 7th ed. Philadelphia: Elsevier; 2012. p. 1037–40.Google Scholar
  5. 5.
    French JA, Williamson PD, Thadani VM, Darcey TM, Mattson RH, Spencer SS, et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol. 1993;34:774–80.CrossRefGoogle Scholar
  6. 6.
    Berg AT, Scheffer IE. New concepts in classification of the epilepsies: entering the 21st century. Epilepsia. 2011;52:1058–62.CrossRefGoogle Scholar
  7. 7.
    Bancaud J, Talairach J. Clinical semiology of frontal lobe seizures. Adv Neurol. 1992;57:3–58.PubMedGoogle Scholar
  8. 8.
    Luders H, Acharya J, Baumgartner C, Benbadis S, Bleasel A, Burgess R, et al. Semiological seizure classification. Epilepsia. 1998;39:1006–13.CrossRefGoogle Scholar
  9. 9.
    Giulioni M, Marucci G, Martinoni M, Marliani AF, Toni F, Bartiromo F, et al. Epilepsy associated tumors: review article. World J Clin Cases. 2014;2:623–41.CrossRefGoogle Scholar
  10. 10.
    Jobst B, Williamson P. Anatomical-clinical localization of ictal behaviour. In: Kaplan PW, Fisher RS, editors. Imitators of epilepsy. 2nd ed. New York: Springer, Demos Medical Publishing; 2005. p. 47–62.Google Scholar
  11. 11.
    Lopez J. Brain-tumor-related epilepsy in children. In: Newton HB, Maschio M, editors. Epilepsy and brain tumors. Boston: Academic; 2015. p. 65–99.CrossRefGoogle Scholar
  12. 12.
    Κάζης Α. Επιληψίες. In: Press US, editor. Κλινική Νευροφυσιολογία. Thessaloniki: University Studio Press; 1984. p. 43–60.Google Scholar
  13. 13.
    Blume TW. Electroencephalography in diagnosis of non-epilectic and epileptic conditions. In: Peter KW, Roberts FF, editors. Imitators of epilepsy. 2nd ed. New York: Springer, Demos Medical Publishing; 2005. p. 33–46.Google Scholar
  14. 14.
    Appleton R, Nicolson A, Smith D, Chadwick D, MacKenzie J. Etiology. Atlas of epilepsy. London: Informa Healthcare; 2007. p. 41–114.Google Scholar
  15. 15.
    Κάζης Α. Όγκοι του εγκεφάλου. In: Press US, editor. Κλινική Νευροφυσioλογία. Θεσσαλονίκη. Thessaloniki: University Studio Press; 1984. p. 61–6.Google Scholar
  16. 16.
    Newton HB, Maschio M. Clinical evaluation of epilepsy in the brain-tumor patient. In: Newton HB, Maschio M, editors. Epilepsy and brain tumors. Boston: Academic; 2015. p. 43.Google Scholar
  17. 17.
    Leslie R, Maschio M, Newton HB. Antiepileptic drugs and brain tumor patients. In: Newton HB, Maschio M, editors. Epilepsy and brain tumors. Boston: Academic; 2015. p. 195–205.CrossRefGoogle Scholar
  18. 18.
    Maschio M. Brain tumor-related epilepsy. Curr Neuropharmacol. 2012;10:124–33.CrossRefGoogle Scholar
  19. 19.
    de Groot M, Reijneveld JC, Aronica E, Heimans JJ. Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain. 2012;135:1002–16.CrossRefGoogle Scholar
  20. 20.
    Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013;54:551–63.CrossRefGoogle Scholar
  21. 21.
    Tremont-Lukats IW, Ratilal BO, Armstrong T, Gilbert MR. Antiepileptic drugs for preventing seizures in people with brain tumors. Cochrane Database Syst Rev. 2008;(2):Cd004424.Google Scholar
  22. 22.
    Grant R. Overview: brain tumour diagnosis and management/royal college of physicians guidelines. J Neurol Neurosurg Psychiatry. 2004;75:ii18–23.CrossRefGoogle Scholar
  23. 23.
    Hildebrand J, Lecaille C, Perennes J, Delattre JY. Epileptic seizures during follow-up of patients treated for primary brain tumors. Neurology. 2005;65:212–5.CrossRefGoogle Scholar
  24. 24.
    Glantz MJ, Cole BF, Forsyth PA, Recht LD, Wen PY, Chamberlain MC, et al. Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors: report of the quality standards Subcommittee of the American Academy of neurology. Neurology. 2000;54:1886–93.CrossRefGoogle Scholar
  25. 25.
    Gallagher P, Leach JP, Grant R. Time to focus on brain tumor-related epilepsy trials. Neuro-Oncol Pract. 2014;1:123–33.CrossRefGoogle Scholar
  26. 26.
    Newton HB, Dalton J, Goldlust S, Pearl D. Retrospective analysis of the efficacy and tolerability of levetiracetam in patients with metastatic brain tumors. J Neuro-Oncol. 2007;84:293–6.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Efthimios Dardiotis
    • 1
  • Maria Sokratous
    • 1
  • Katerina Markou
    • 1
  • Georgios M. Hadjigeorgiou
    • 1
  1. 1.Department of NeurologyUniversity Hospital of Larisa/Mezourlo LarisaLarisaGreece

Personalised recommendations