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Oxidative Stress in Ocular Disorders: Exploring the Link to Pesticide Exposure and Potential for Using Nanotechnology for Antioxidant Delivery

  • Pavan Sunkireddy
  • Bhasker Sriramoju
  • Kislay Roy
  • Rupinder Kaur Kanwar
  • Jagat Rakesh Kanwar
Chapter

Abstract

Ocular toxicity caused due to pesticide-induced oxidative stress is a topic of great interest in toxicological research in the recent past. The human eye is directly exposed to various toxins especially pesticides. Exposure to pesticides through various routes could lead to severe ocular disorders due to oxidative stress. Antioxidant biomolecules have a great potential to combat the effects of pesticides in ocular structures. Most of these antioxidant biomolecules lack bioavailability in ocular structures; hence developing a novel nanoparticle-based antioxidant formulation could solve this issue and can offer maximum therapeutic potential for antioxidant biomolecules in prevention/control of ocular toxicity induced by pesticide. This review gives a cumulated information on various reported studies on pesticide-induced oxidative stress and how it may cause ocular toxicity. Further in this review, we have discussed how nanotechnology product-based delivery of antioxidant biomolecules could reflect on their therapeutic potential in prevention or control of pesticide-induced oxidative stress and its further effect on ocular health.

Keywords

Pesticides Oxidative stress Ocular toxicity Antioxidants Nanotechnology 

Notes

Acknowledgment

Authors are thankful to the National Health and Medical Research Council (NHMRC; APP1050286) and Australia-India Strategic Research Fund (AISRF). The research fellowship to Pavan Sunkireddy from Deakin University is highly acknowledged.

Declaration of Interest

The author reports no declarations of interest. This work was supported by grants from Australia-India Strategic Research Fund (AISRF) and Deakin University.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Pavan Sunkireddy
    • 1
    • 2
  • Bhasker Sriramoju
    • 1
  • Kislay Roy
    • 1
  • Rupinder Kaur Kanwar
    • 1
  • Jagat Rakesh Kanwar
    • 1
  1. 1.Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Centre for Molecular and Medical Research (MMR), Faculty of Health, Deakin UniversityGeelongAustralia
  2. 2.Biotechnology and Management of Bioresources Division The Energy and Resources Institute Darbari Seth Block, India Habitat CentreNew DelhiIndia

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