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Drug Delivery for the Retina and Posterior Segment Disease pp 51–67Cite as

Drug Delivery to Posterior Segment of the Eye: Conventional Delivery Strategies, Their Barriers, and Restrictions

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Abstract

Posterior eye segment diseases have been a crucial health ailment for years due to the anatomical structure of the human eye and the challenges to deliver drugs to certain tissues in the eye. This chapter discusses the parts of the posterior segment and its functions along with the possible barriers to conventional treatments. Topical and systematic drug delivery systems are traditional ways of treating most ocular diseases. However, these are not as effective due to low absorption, degradation of the therapeutic agents via enzymes, and toxicity due to higher drug doses to compensate for the low permeability. On the other hand, intravitreal, transscleral diffusion and iontophoresis along with ocular implants are novel techniques that increase the bioavailability as well as precision of the drug delivery.

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Authors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), ITI Compound, Raebareli, UP, India

    Deepak Yadav & Lanke Tejesh Varma

  2. School of Pharmacy, Hadassah Medical Centre, The Hebrew University of Jerusalem, Ein Kerem Campus, Jerusalem, Israel

    Deepak Yadav

  3. Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India

    Kiran Yadav

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  1. Faculty of Pharmacy, Sankalchand Patel University, Gujarat, India

    Jayvadan K. Patel

  2. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Vijaykumar Sutariya

  3. School of Medicine, Faculty of Health, Deakin University, Victoria, Australia

    Jagat Rakesh Kanwar

  4. College of Pharmacy, University of South Florida, Tampa, FL, USA

    Yashwant V. Pathak

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Yadav, D., Varma, L.T., Yadav, K. (2018). Drug Delivery to Posterior Segment of the Eye: Conventional Delivery Strategies, Their Barriers, and Restrictions. In: Patel, J., Sutariya, V., Kanwar, J., Pathak, Y. (eds) Drug Delivery for the Retina and Posterior Segment Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-95807-1_3

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