Intravitreal Injection Drug Delivery for Retina and Posterior Segment Disease: Challenges and the Future Ahead
Intravitreal drug delivery system has been found to successfully cross the blood-ocular barrier and providing an immediate healing effect. Although these advantages help in overcoming the challenges faced by conventional treatment methods, intravitreal injections have to be given by a skilled physician with precaution. Currently, the novel implants could replace injections, which prevent the side effects. The implants or injections can contain formulations involving liposomes, nanoparticles, and hydrogels to administer sustained drug release to the ocular tissues. Sterilization is ensured via the use of membrane filters for aqueous and oil-based solutions. Meanwhile, stability of active ingredients is preserved by controlling its storage environment. The hydrogel contact lens drug delivery system and suprachoroidal space (SCS) system have displayed great improvement in targeting precision when tested on animals. With recent studies involving in vivo and ex vivo models, the chapter briefly talks about the advances as well as drawbacks in terms of tackling ocular diseases.
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