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Receptor-Targeted Prodrug Approach for Retina and Posterior Segment Disease

  • Tejal Mehta
  • Viral Patel
  • Om Prakash Sharma
Chapter

Abstract

Extensive research has been done in the field of ocular study, to develop and to enhance ocular bioavailability of drugs. Regardless it still faces challenges, as less than 5% of the dose administered reaches to the target site, which is insufficient to produce a pharmacological effect. The chemical methods including the development of prodrugs have proven to be a promising approach to improve ocular drug residence time and bioavailability.

Utilization of prodrugs for the treatment of posterior segment diseases was observed to be an innovative way to overcome barriers pertaining to drug delivery to the specific site. Prodrug effectively permeates the external ocular barriers, cornea and scleral tissues and has a greater partition coefficient. Prodrug approach offers a few points of interest like enhancement of drug solubility, stability, site-specific delivery, decreased toxicity and efflux pump evasion. This section stresses on hypothesis and uses of receptor-focused prodrug approach for ocular drug delivery systems.

Abbreviations

ACV

Acyclovir

ARMD/AMD

Age-related macular degeneration

AV

Arterial vein

BOB

Blood–ocular barrier

BRB

Blood–retinal barrier

BRVO

Branched retinal vein occlusion

CRVO

Central retinal vein occlusion

EAAT

Excitatory amino acid receptors

GABA

Gamma amino butyric acid

GCV

Ganciclovir

HR

Hypertensive retinopathy

HSV

Herpes simplex virus

IV

Intravenous

MCTs

Monocarboxylic acid transporters

PCFT

Proton-coupled folate transporter

P-gp

P-glycoprotein

PHVP

Persistent hyperplastic primary vitreous

PVD

Posterior vitreous detachments

RBCs

Red blood cells

RFC

Reduced folate carrier

RVO

Retinal vein occlusion

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PharmaceuticsInstitute of Pharmacy, Nirma UniversityAhmedabadIndia
  2. 2.Pharmaceutical Technology Centre, Cadila Healthcare LimitedAhmedabadIndia

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