Transporter-Targeted Prodrug Approach for Retina and Posterior Segment Disease
Prodrug strategy is used to increase the bioavailability of drugs either by increasing the passive absorption by improving physicochemical properties of the parent drug or making them substrates of active transporter. There have been numerous reports and clinical applications of various prodrugs for oral delivery. Transporter-mediated prodrug approach is still a new and not completely explored area in the case of ocular delivery. This chapter gives a brief snapshot of the transporter-mediated prodrug approach for ocular delivery of drugs. There is also brief account of other types of prodrugs used for improving ocular bioavailability.