Radionuclide Imaging of Cardiovascular Disease

  • Matteo Bauckneht
  • Flavia Ticconi
  • Roberta Piva
  • Riemer H. J. A. Slart
  • Alberto Nieri
  • Silvia Morbelli
  • Paola Anna Erba
  • Cecilia Marini
  • H. William Strauss
  • Gianmario SambucetiEmail author


Multiple imaging modalities are clinically available for evaluation of global and regional cardiac function, determination of regional myocardial perfusion, and evaluation of coronary anatomy, including SPECT with CT, PET with CT, multi-detector computed tomography (MDCT), magnetic resonance imaging (MRI), and ultrasound. Emblematic of this revolution is the capability of cardiac MDCT to integrate evaluation of coronary artery anatomy with noninvasive assessment of myocardial perfusion and contractile function [1]. MDCT still needs to be technically optimized, particularly to identify small changes in myocardial perfusion, which can be done reproducibly with radionuclide techniques [2]. On the other hand, despite proven clinical efficacy in the detection of CAD (primarily based on the presence of calcium in the coronary arteries), MDCT imaging performs suboptimally in the noninvasive characterization of multivessel CAD. On the other hand, the specificity of nuclear imaging is improved by attenuation correction. Accordingly, multimodality SPECT/CT or PET/CT approach is the current standard for evaluating myocardial perfusion.


Coronary artery disease Myocardial blood flow Pathophysiology of coronary circulation Myocardial ischemia Angina Acute myocardial infarction Stress myocardial perfusion imaging Rest myocardial perfusion imaging Exercise stress testing Pharmacologic stress testing Adenosine Regadenoson Dipyridamole Dobutamine 201Tl-chloride 99mTc-sestamibi 99mTc-tetrofosmin SPECT Myocardial viability PET/CT Rubidium-82 82Sr/82Rb generator [15O]Water [13N]Ammonia Infective endocarditis Cardiovascular implantable electronic devices Implantable left ventricular assist devices 99mTc-HMPAO-WBC SPECT/CT [18F]FDG PET/CT Prosthetic valve endocarditis Native valve endocarditis Vascular prosthetic infection Myocarditis Acute pericarditis Cardiac sarcoidosis Cardiac amyloidosis Heart failure 123I-MIBG Heart-to-mediastinum ratio Large vessel vasculitis 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Matteo Bauckneht
    • 1
  • Flavia Ticconi
    • 2
  • Roberta Piva
    • 2
  • Riemer H. J. A. Slart
    • 3
  • Alberto Nieri
    • 2
  • Silvia Morbelli
    • 1
    • 2
  • Paola Anna Erba
    • 4
  • Cecilia Marini
    • 2
    • 5
  • H. William Strauss
    • 6
  • Gianmario Sambuceti
    • 1
    • 2
    Email author
  1. 1.Nuclear MedicineIRCCS Policlinico San MartinoGenoaItaly
  2. 2.Nuclear Medicine, Department of Health SciencesUniversity of GenoaGenoaItaly
  3. 3.Biomedical Photonic Imaging GroupUniversity of TwenteEnschedeThe Netherlands
  4. 4.Regional Center of Nuclear Medicine, Department of Translational Research and Advanced Technologies in Medicine and SurgeryUniversity of PisaPisaItaly
  5. 5.CNR Institute of Bioimages and Molecular PhysiologyMilanItaly
  6. 6.Molecular Imaging and Therapy ServiceMemorial Sloan Kettering Cancer CenterNew YorkUSA

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