Imitation of Life: The Cell in a Silicon Chip

  • Sergio Carrà
Part of the The Frontiers Collection book series (FRONTCOLL)


I thought there couldn’t be anything as complicated as the universe, until I started reading about the cell”, wrote the astrophysicist Eric de Silva.


  1. Covert, Marcus W., Christophe H. Schilling, Bernhard Palsson. Regulation of Gene Expression in Flux Balance Models of Metabolism, J. theor. Biol. (2001) 213, 73–88.CrossRefGoogle Scholar
  2. Gánti, T., 1971, 1987. The Principle of Life. Omikk, Budapest, Hungary (Translated into English 1987).Google Scholar
  3. Macklin, Derek N, Nicholas A Ruggero and Markus W Covert. The future of whole-cell modeling, Current Opinion in Biotechnology 2014, 28:111–115.CrossRefGoogle Scholar
  4. McCloskey, Douglas, Bernhard Ø Palsson and Adam M Feist. Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli, Molecular Systems, Biology (2013) 9:661.
  5. Simpson Michael, Gary S. Sayler, James T. Fleming, Bruce Applegate. Whole cell biocomputing, TRENDS in Biotechnology Vol.19 No.8 August 2001 317.CrossRefGoogle Scholar
  6. Schilling, Christophe H., Stefan Schuster, Bernhard O. Palsson, and Reinhart Heinrich. Metabolic Pathway Analysis: Basic Concepts and Scientific Applications in the Post-genomic, Biotechnol. Prog. 1999, 15, 296−303.Google Scholar
  7. Simpson, Michael L. et al. Engineering in the Biological Substrate: Information Processing in Genetic Circuits, PROCEEDINGS OF THE IEEE, VOL. 92, NO. 5, MAY 2004.Google Scholar
  8. Cheemeng Tan, Hao Song, Jarad Niemi and Lingchong You. A synthetic biology challenge: making cells compute, Mol. BioSyst., 2007, 3, 343–353.CrossRefGoogle Scholar
  9. Thiele, Ines, Neema Jamshidi, Ronan M. T. Fleming, Bernhard Ø. Palsson. Genome-Scale Reconstruction of Escherichia coli’s Transcriptional and Translational Machinery: A Knowledge Base, Its Mathematical Formulation, and Its Functional Characterization, PLoS Computational Biology, March 2009 | Volume 5 | Issue 3 | pag.1.Google Scholar
  10. Masaru Tomita. Whole-cell simulation: a grand challenge of the 21st century, TRENDS in Biotechnology Vol.19 No.6 June 2001 205.CrossRefGoogle Scholar
  11. Masaru Tomita, Kenta Hashimoto, Kouichi Takahashi, Thomas Simon Shimizu, Yuri Matsuzaki, Fumihiko Miyoshi, Kanako Saito, Sakura Tanida, Katsuyuki Yugi, J. Craig Venter and Clyde A. Hutchison. E-CELL: software environment for whole-cell simulation, Bioinformatics, Vol. 15 no. 1 1999 Pages 72–84.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Sergio Carrà
    • 1
  1. 1.Department of Chemistry, Materials and Chemical EngineeringPolytechnic UniversityMilanItaly

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