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Signals and Molecular Mechanisms Regulating Stem Cell Behavior in Other Systems (e.g., Hematopoietic Stem Cells)

  • Ahmed El-Hashash
Chapter
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Abstract

Over recent years, many studies of stem cell behavior in different organs have accumulated evidences on the molecular mechanisms and signaling pathways that regulate key aspects of stem/progenitor cell behavior such as self-renewal, differentiation, and apoptosis. These molecular mechanisms include Wnt, TGF beta, and Notch signaling pathways that are well investigated in hematopoietic stem cells. In this chapter, we will discuss the hematopoietic stem/progenitor cell niche and both the molecular mechanisms and signaling pathways that control their behavior since this will improve our understanding of the role of these mechanisms and signals in the behavior of lung stem/progenitor cells that is still not well studied compared to hematopoietic stem/progenitor cells.

Keywords

Stem cells Cell behavior Cell fate Hematopoietic stem cells Wnt Notch TGF Signaling pathway 
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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ahmed El-Hashash
    • 1
  1. 1.The University of Edinburgh-Zhejiang International campus (UoE-ZJU Institute), and Centre of Stem Cell and Regenerative Medicine Schools of Medicine & Basic Medicine, Zhejiang UniversityHainingChina

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