Role of Insulin-Like Growth Factor Receptors in Cancer Signaling
The insulin-like growth factor signaling system has been implicated in cancer etiology, progression, and metastasis. This signaling system involves a network of highly related ligands and receptors. Targeting of this system is complex; multiple receptors, including the insulin receptor, are involved. Further, holo- and hybrid receptors must be considered when considering therapeutic strategies. This review will evaluate the signaling pathways mediated by this system.
KeywordsInsulin Insulin-like growth factors Type I insulin-like growth factor receptor Insulin receptor Tyrosine kinase
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