• Stephen H. Tsang
  • Tarun SharmaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1085)


  • Syphilis is an infectious disease caused by a spirochete, Treponema pallidum; it is most commonly spread by sexual transmission.

  • Syphilis is known as the “Great Imitator,” as systemic manifestations are variable. It can involve any part of the eye, with syphilitic uveitis being the most common type.

  • Congenital syphilis is characterized by Hutchinson’s teeth, saddle nose deformity, deafness, and interstitial keratitis; pigmentary changes in the retina are varied and patchy.


Phenocopies Syphilis 

Suggested Reading

  1. Asensio-Sánchez VM. Syphilitic chorioretinitis: final outcome without treatment. Arch Soc Esp Oftalmol. 2018; [Epub ahead of print].CrossRefGoogle Scholar
  2. Tsui E, Gal-Or O, Ghadiali Q, Freund KB. Multimodal imaging adds new insights into acute syphilitic posterior placoid chorioretinitis. Retin Cases Brief Rep. 2017; [Epub ahead of print].CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Jonas Children’s Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia UniversityNew YorkUSA
  2. 2.Department of Ophthalmology, Columbia UniversityEdward S. Harkness Eye Institute, NewYork-Presbyterian HospitalNew YorkUSA

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