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Two Sides to Every Story: Growing Up with Agenesis of the Corpus Callosum

  • Jay A. Salpekar
  • Aaron J. Hauptman
Chapter

Abstract

The corpus callosum is the largest white matter structure in the human brain. Among other functions, it permits communication between the two cerebral hemispheres. Many psychiatric, neurocognitive, and neurologic conditions are associated with malformation of, or injury to, the corpus callosum. This is a case of an adolescent struggling with a genetic illness, seizure disorder, and problems with pragmatic language. In this case, the existence of agenesis of the corpus callosum proved to have marked effects cognitively and socially and led to difficulties in mitigating anxiety with verbal reassurance. In this patient, the complex function of the corpus callosum is demonstrated by social, emotional, language, and psychiatric effects associated with its congenital malformation.

Keywords

Anxiety Developmental disability Corpus callosum agenesis Trisomy 16 Epilepsy Obsessive compulsive disorder 

References

  1. 1.
    Benn P. Trisomy 16 and trisomy 16 mosaicism: a review. Am J Med Genet. 1998;79:121–33.CrossRefGoogle Scholar
  2. 2.
    Badaruddin DH, Andrews GL, Bolte S, Schilmoeller KJ, Schilmoeller G, Paul LK, Brown WS. Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry Hum Dev. 2007;38:287–302.CrossRefGoogle Scholar
  3. 3.
    Palmer EE, Mowat D. Agenesis of the corpus callosum: a clinical approach to diagnosis. Am J Med Genet C: Semin Med Genet. 2014;166C:184–97.CrossRefGoogle Scholar
  4. 4.
    Yasar AS, Monkul ES, Sassi RB, Axelson D, Brambilla P, Nicoletti MA, Hatch JP, Keshavan M, Ryan N, Birmaher B, Soares JC. MRI study of corpus callosum in children and adolescents with bipolar disorder. Psychiatry Res. 2006;146:83–5.CrossRefGoogle Scholar
  5. 5.
    Plessen KJ, Gruner R, Lundervold A, Hirsch JG, Xu D, Bansal R, Hammar A, Lundervold AJ, Wentzel-Larsen T, Lie SA, Gass A, Peterson BS, Hugdahl K. Reduced white matter connectivity in the corpus callosum of children with Tourette syndrome. J Child Psychol Psychiatry. 2006;47:1013–22.CrossRefGoogle Scholar
  6. 6.
    Paul LK. Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement. J Neurodev Disord. 2011;3:3–27.CrossRefGoogle Scholar
  7. 7.
    Paul LK, Corsello C, Kennedy DP, Adolphs R. Agenesis of the corpus callosum and autism: a comprehensive comparison. Brain. 2014;137:1813–29.CrossRefGoogle Scholar
  8. 8.
    Booth R, Wallace GL, Happe F. Connectivity and the corpus callosum in autism spectrum conditions: insights from comparison of autism and callosal agenesis. Prog Brain Res. 2011;189:303–17.CrossRefGoogle Scholar
  9. 9.
    Ma Y. Neuropsychological mechanism underlying antidepressant effect: a systematic meta-analysis. Mol Psychiatry. 2015;20:311–9.CrossRefGoogle Scholar
  10. 10.
    Taber KH, Salpekar J, Wong AH, Hurley RA. Developmental origins for neuropsychiatric illness. J Neuropsychiatr Clin Neurosci. 2011;23:1–5.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jay A. Salpekar
    • 1
  • Aaron J. Hauptman
    • 2
    • 3
  1. 1.Kennedy Krieger InstituteJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Psychiatry, Boston Children’s HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA

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