Sensors Based on Conducting Polymers for the Analysis of Food Products

  • Constantin Apetrei
  • Mateus D. Maximino
  • Cibely S. Martin
  • Priscila AlessioEmail author


Quality and safety have become important food attributes within the last years. With the expansion of food industry and food fabrication on a big scale is not infrequent to found adulterant and contaminant on food, i.e. of harmful chemicals and microorganisms, which can cause consumer illness. Increasingly, the public authorities are charging the food industry to develop quality management systems and restructure the food inspection system to improve food quality and safety. However, contamination can be taking place during all steps of food manufacturing. For instance, even during storage, the products can experience a significant degradation in quality due to a variety of physical, chemical, and biological interactions. Consequently, fast and inexpensive ways to control the food freshness, contamination or adulteration are requested to keep the quality control. Thus, there is an increasing demand for analytical methods easily operate with highly sensitive, selective and accurate for determining compounds in foods in general. We present here a review about conducting polymers and their application on the development of electrical and electrochemical sensors for detection of contamination or adulteration in food samples.


Biosensor Conductive polymers Electrochemical sensor Electronic nose Food samples 


  1. Abbey BL, Joyce DC, Aked J et al (2004) Electronic nose evaluation of onion headspace volatiles and bulb quality as affected by nitrogen, sulphur and soil type. Ann Appl Biol 145(1):41–50CrossRefGoogle Scholar
  2. Al-Anati L, Petzinger E (2006) Immunotoxic activity of ochratoxin A. J Vet Pharmacol Ther 29:79–90CrossRefPubMedGoogle Scholar
  3. Apetrei IM, Apetrei C (2013) Amperometric biosensor based on polypyrrole and tyrosinase for the detection of tyramine in food samples. Sensors Actuators B Chem 178:40–46. Scholar
  4. Ateh DD, Navsaria HA, Vadgama P (2006) Polypyrrole-based conducting polymers and interactions with biological tissues. J R Soc Interface 3(11):741–752. Scholar
  5. Balint R, Cassidy NJ, Cartmell SH (2014) Acta biomaterialia conductive polymers: towards a smart biomaterial for tissue engineering. Acta Biomater 10:2341–2353. Scholar
  6. Barber RS, Braude R, Hosking ZD, Mitchell KG (1979) Olaquindox as performance-promoting feed additive for growing pigs. Anim Feed Sci Technol 4:117–123. Scholar
  7. Bard A, Rubenstein I (1996) Electroanalytical chemistry: a series of advances. CRC PressGoogle Scholar
  8. Bartlett PN, Whitaker RG (1987) Strategies for the development of amperometric enzyme electrodes. Biosensors 3:359–379. Scholar
  9. Berndt J, Pattyn C, Hussain S, Kovacevic E (2017) Plasma based synthesis of conductive polymers: experimental results and some remarks about general strategies for plasma based polymerization processes. ECS Trans 77:49–52CrossRefGoogle Scholar
  10. Boeva ZA, Sergeyev VG (2014) Polyaniline: synthesis, properties, and application. Polym Sci Ser C 56:144–153. Scholar
  11. Bonifas AP, Mccreery RL (2012) Solid state spectroelectrochemistry of redox reactions in polypyrrole/oxide molecular heterojunctions. Anal Chem 84(5):2459–2465. Scholar
  12. Bossi A, Bonini F, Turner APF, Piletsky SA (2007) Molecularly imprinted polymers for the recognition of proteins: the state of the art. Biosens Bioelectron 22:1131–1137. Scholar
  13. Brooke R, Mitraka E, Sardar S et al (2017) Infrared electrochromic conducting polymer devices. J Mater Chem C 5:5824–5830. Scholar
  14. Bunting RK, Swarat K, Yan D et al (1997) Synthesis and characterization of a conducting polymer: an electrochemical experiment for general chemistry. J Chem Educ 74:421–422CrossRefGoogle Scholar
  15. Burgmayer P, Murray RW, Hill C, Carolina N (1982) An ion gate membrane: electrochemical control of ion permeability through a membrane with an embedded electrode. J Am Chem Soc 104(6139–6140):6139–6140. Scholar
  16. Chapuis-Hugon F (2008) Role of molecularly imprinted polymers for selective determination of environmental pollutants—a review. Anal Chim Acta 622(1–2):48–61. Scholar
  17. Chen X, Wang F, Chen Z (2008) An electropolymerized Nile Blue sensing film-based nitrite sensor and application in food analysis. Anal Chim Acta 623:213–220. Scholar
  18. Cooper JC, Hall EAH (1992) Electrochemical response of an enzyme-loaded polyaniline film. Biosens Bioelectron 7:473–485. Scholar
  19. D’Elia LF, Ortızz RL, Márquez OP, Márquez J, Martínez Y (2001) Electrochemical deposition of poly(o-phenylenediamine) films on type 304 stainless steel. J Electrochem Soc 148(2):297–300. Scholar
  20. Dai L (2004) Intelligent macromolecules for smart devices: from materials synthesis to device applications. Springer, LondonGoogle Scholar
  21. Dubey S, Prasad BM, Misra RA (1999) Electrochemical synthesis and properties of poly(3-methylthiophene): novel synthesis of poly(3-methylthiophene) with pentachlorostannate and hexachloroantimonate. J Appl Polym Sci 73:91–102CrossRefGoogle Scholar
  22. Efimov ON, Chem R (1997) Polypyrrole: a conducting polymer; its synthesis, properties and applications. Russ Chem Rev 66(5):443–457CrossRefGoogle Scholar
  23. Feast W, Tsibouklis J, Pouwer K et al (1996) Synthesis, processing and material properties of conjugated polymers. Polymer 37:5017–5047CrossRefGoogle Scholar
  24. Fichou D (2008) Handbook of oligo- and polythiophenes. Wiley, WeinheimGoogle Scholar
  25. Filik H, Avan AA, Mümin Y (2017) Simultaneous electrochemical determination of caffeine and vanillin by using poly(Alizarin Red S) modified glassy carbon electrode. Food Anal Methods 10:31–40. Scholar
  26. Gerard M (2002) Application of conducting polymers to biosensors. Biosens Bioelectron 17:345–359. Scholar
  27. Geto A, Tessema M, Admassie S (2014) Determination of histamine in fish muscle at multi-walled carbon nanotubes coated conducting polymer modified glassy carbon electrode. Synth Met 191:135–140. Scholar
  28. Ghosh (Hazra) S, Sarker D, Misra TN (1998) Development of an amperometric enzyme electrode biosensor for fish freshness detection. Sensors Actuators B Chem 53:58–62. Scholar
  29. Guadarrama A, Rodrıguez-Méndez ML, Sanz C et al (2001) Electronic nose based on conducting polymers for the quality control of the olive oil aroma: discrimination of quality, variety of olive and geographic origin. Anal Chim Acta 432:283–292CrossRefGoogle Scholar
  30. Guadarrama A, Rodrıguez-Méndez ML, De Saja JA (2004) Influence of electrochemical deposition parameters on the performance of poly-3-methyl thiophene and polyaniline sensors for virgin olive oils. Sensors Actuators B Chem 100:60–64. Scholar
  31. Gvozdenovi MM, Jugovi BZ, Stevanovi JS, Grgur BN (2014) Electrochemical synthesis of electroconducting polymers. Hem Ind 68(6):673–684. Scholar
  32. Heeger A (1985) Charge storage in conducting polymers—solitons, polarons, and bipolarons. Polym J 17:201–208CrossRefGoogle Scholar
  33. Hossain E, Rahman GMA, Freund MS et al (2012) Fabrication and optimization of a conducting polymer sensor array using stored grain model volatiles. J Agric Food Chem 60(11):2863–2873. Scholar
  34. Hosseini AR, Wong MH, Shen Y et al (2017) Charge injection in doped organic semiconductors Charge injection in doped organic semiconductors. J Appl Phys 97:23705. Scholar
  35. Inzelt G (2017) Recent advances in the field of conducting polymers. J Solid State Electrochem 21:1965–1975. Scholar
  36. Isaacs M, Armijo F, Ram G et al (2005) Electrochemical reduction of CO 2 mediated by poly-M-aminophthalocyanines (M = Co, Ni, Fe): poly-Co-tetraaminophthalocyanine, a selective catalyst. J Mol Catal A Chem 229:249–257. Scholar
  37. Kaur G, Adhikari R, Cass P et al (2015) Electrically conductive polymers and composites for biomedical applications. RSC Adv 5:37553–37567. Scholar
  38. Kausar A (2017) Overview on conducting polymer in energy storage and energy conversion system. J Macromol Sci Part A 54:640–653. Scholar
  39. Khan A, Jawaid M, Khan A, Asiri A (2018) Electrically conductive polymers and polymer composites: from synthesis to biomedical applications. Wiley, WeinheimCrossRefGoogle Scholar
  40. Kranz C, Wohlschläger H, Schmidt H-L, Schuhmann W (1998) Controlled electrochemical preparation of amperometric biosensors based on conducting polymer multilayers. Electroanalysis 10(8):546–552.<546::AID-ELAN546>3.0.CO;2-#CrossRefGoogle Scholar
  41. Labaye DE, Jérôme C, Geskin VM et al (2002) Full electrochemical synthesis of conducting polymer films chemically grafted to conducting surfaces. Langmuir 18:5222–5230. Scholar
  42. Lach P, Sharma PS, Golebiewska K et al (2017) Molecularly imprinted polymer chemosensor for selective determination of an N-nitroso-l-proline food toxin. Chem Eur J 23:1942–1949. Scholar
  43. Longo L, Vasapollo G (2008) Molecularly imprinted polymers as nucleotide receptors. Mini Rev Org Chem 5(3):163–170CrossRefGoogle Scholar
  44. Macdiarmid AG, Epstein AJ (1995) Secondary doping: a new concept in conducting polymers. Macromol Symp 98:835–842CrossRefGoogle Scholar
  45. Malinauskas A (1999) Electrocatalysis at conducting polymers. Synth Met 107:75–83. Scholar
  46. Mason E, Weber A (2011) Polypyrrole: properties, performance and applications. Nova Science Publisher, New YorkGoogle Scholar
  47. Matindoust S, Farzi A, Baghaei M (2017) Ammonia gas sensor based on flexible polyaniline films for rapid detection of spoilage in protein-rich foods. J Mater Sci Mater Electron 28:7760–7768. Scholar
  48. Morelli I, Chiono V, Vozzi G et al (2010) Sensors and actuators B: chemical molecularly imprinted submicronspheres for applications in a novel model biosensor-film. Sensors Actuators B Chem 150:394–401. Scholar
  49. Neely K, Taylor C, Prosser O, Hamlyn PF (2001) Assessment of cooked alpaca and llama meats from the statistical analysis of data collected using an ‘electronic nose. Meat Sci 58:53–58CrossRefPubMedGoogle Scholar
  50. Okabayashi K, Goto F, Abe K, Yoshida T (1987) Electrochemical studies of polyaniline and its application. Synth Met 18:365–370. Scholar
  51. Onal A (2007) A review: current analytical methods for the determination of biogenic amines in foods. Food Chem 103(4):1475–1486. Scholar
  52. Pacheco JG, Castro M, Machado S et al (2015) Molecularly imprinted electrochemical sensor for ochratoxin A detection in food samples. Sensors Actuators B Chem 215:107–112. Scholar
  53. Palmisano F, Rizzi R, Centonze D, Zambonin PG (2000) Simultaneous monitoring of glucose and lactate by an interference and cross-talk free dual electrode amperometric biosensor based on electropolymerized thin films. Biosens Bioelectron 15:531–539. Scholar
  54. Pern F, Frank AJ (1990) Electrochemical and optical characterization of poly(3‐methylthiophene): effects of solvent, anion, and applied potential. J Electrochem Soc 137:2769–2777CrossRefGoogle Scholar
  55. Priyanka D, Venkatesh KS, Science M (2015) Synthesis, characterization and electrical properties of polyaniline doped with different acids. Int J Eng Res Appl 5:53–61Google Scholar
  56. Puoci F, Cirillo G, Curcio M et al (2007) Molecularly imprinted solid phase extraction for the selective HPLC determination of α-tocopherol in bay leaves. Anal Chim Acta 593(2):164–170. Scholar
  57. Ramström O, Mosbach K (1999) Synthesis and catalysis by molecularly imprinted materials. Curr Opin Chem Biol 3(6):759–764CrossRefPubMedGoogle Scholar
  58. Rañola RAG, Santiago KS, Sevilla FB (2016) Use of array of conducting polymers for differentiation of coconut oil products. Talanta 146:75–82. Scholar
  59. Ravichandran R, Sundarrajan S, Venugopal JR et al (2010) Applications of conducting polymers and their issues in biomedical engineering. J R Soc Interface 7:S559–S579. Scholar
  60. Ridgway C, Chambers J, Portero-Larragueta E, Prosser O (1999) Detection of mite infestation in wheat by electronic nose with transient flow sampling. J Sci Food Agric 19(15):2067–2074CrossRefGoogle Scholar
  61. Rotariu L, Lagarde F, Jaffrezic-Renault N, Bala C (2016) Electrochemical biosensors for fast detection of food contaminants—trends and perspective. TrAC Trends Anal Chem 79:80–87. Scholar
  62. Saber-Tehrani M, Pourhabib A, Husain SW, Arvand M (2013) A simple and efficient electrochemical sensor for nitrite determination in food samples based on Pt nanoparticles distributed poly(2-aminothiophenol) modified electrode. Food Anal Methods 6:1300–1307. Scholar
  63. Sahmetlioglu E, Yuruk H, Toppare L, Yagci Y (2009) Synthesis and characterization of conducting copolymers of bisphenol A-diglycidyl ether with thiophene side-groups and pyrrole. J Macromol Sci A 46(6):37–41. Scholar
  64. Sapurina IY, Shishov M (2012) Oxidative polymerization of aniline: molecular synthesis of polyaniline and the formation of supramolecular structures. In: Gomes ADS (ed) New polymers for special applications. InTechGoogle Scholar
  65. Sarafraz-Yazdi A, Razavi N (2015) Application of molecularly-imprinted polymers in solid-phase microextraction techniques. Trends Anal Chem 73:81–90. Scholar
  66. Schlereth DD, Karyakin AA (1995) Electropolymerization of phenothiazine, phenoxazine and phenazine derivatives: characterization of the polymers by UV-visible difference spectroelectrochemistry and Fourier transform IR spectroscopy. J Electroanal Chem 395:221–232. Scholar
  67. Scorrano S, Mergola L, Del Sole R et al (2011) Synthesis of molecularly imprinted polymers for amino acid derivates by using different functional monomers. Int J Mol Sci 12(3):1735–1743. Scholar
  68. Shirakawa H, Macdiarmid AG (1977) Electrical conductivity in doped polyacetylene. Phys Rev Lett 24(39):1098–1101Google Scholar
  69. Shirakawa H, Louis EJ, MacDiarmid AG et al (1977a) Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x. J Chem Soc Chem Commun 16:578–580. Scholar
  70. Shirakawa H, Louis E, Macdiarmid A et al (1977b) Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene. J Chem Soc Chem Commun 16:578–580CrossRefGoogle Scholar
  71. Siegmund B, Pfannhauser W (1999) Changes of the volatile fraction of cooked chicken meat during chill storing: results obtained by the electronic nose in comparison to GC-MS and GC olfactometry. Zeitschrift für Lebensmitteluntersuchung und Forschung A 208(5–6):336–341CrossRefGoogle Scholar
  72. Skotheim T (1997) Handbook of conducting polymers, 2nd edn. CRC Press, Boca Raton, FLGoogle Scholar
  73. Skotheim T, Elsenbaumer R, Reynolds J (1995) Handbook of conducting polymers. Marcel Dekker, New YorkGoogle Scholar
  74. Sotzing GA, Phend JN, Grubbs RH, Lewis NS (2000) Highly sensitive detection and discrimination of biogenic amines utilizing arrays of polyaniline/carbon black composite vapor detectors. Chem Mater 12(3):593–595. Scholar
  75. Spanier A, Beaulieu J, Bett K, Gross K (1999) Use of electronic nose technology to examine apple quality. In: Shahidi F, Ho CT (eds) Flavor chemistry of ethnic foods. Springer, Boston, MAGoogle Scholar
  76. Steffens C, Franceschi E, Corazza FC et al (2010) Gas sensors development using supercritical fluid technology to detect the ripeness of bananas. J Food Eng 101:365–369. Scholar
  77. Stella R, Barisci JN, Serra G et al (2000) Characterisation of olive oil by an electronic nose based on conducting polymer sensors. Sensors Actuators B Chem 63(1–2):1–9CrossRefGoogle Scholar
  78. Steter JR, Pontólio JO, Campos MLAM, Romero JR (2008) Modified electrodes prepared with polyphenolic film containing ruthenium complex and metal ligand anchored by azo covalent bond. J Braz Chem Soc 19:660–666. Scholar
  79. Su W, Schrieffer R, Heeger A (1979) Solitons in polyacetylene. Phys Rev Lett 42:1698–1701CrossRefGoogle Scholar
  80. Tamayo FG, Casillas JL, Martin-Esteban A (2005) Clean up of phenylurea herbicides in plant sample extracts using molecularly imprinted polymers. Anal Bioanal Chem 381:1234–1240. Scholar
  81. Taylor P, Das TK, Prusty S (2012) Polymer-plastics technology and engineering review on conducting polymers and their applications. Polym Plast Technol Eng 51(14):37–41. Scholar
  82. Thanh-Hai L, Kim Y, Yoon H (2017) Electrical and electrochemical properties of conducting polymers. Polymers 9:1–32. Scholar
  83. Thiemann C, Brett CMA (2001) Electrosynthesis and properties of conducting polymers derived from aminobenzoic acids and from aminobenzoic acids and aniline. Synth Met 123:1–9. Scholar
  84. Tiggemann L, Ballen SC, Bocalon CM et al (2017) Electronic nose system based on polyaniline films sensor array with different dopants for discrimination of artificial aromas. Innovative Food Sci Emerg Technol 43:112–116. Scholar
  85. Torresi RM, Córdoba de Torresi SI, Matencio T, de Paoli MA (1995) Ionic exchanges in dodecylbenzenesulfonate-doped polypyrrole Part II: Electrochemical quartz crystal microbalance study. Synth Met 72:283–287CrossRefGoogle Scholar
  86. Trojanowicz M, Krawczyński vel Krawczyk T (1995) Electrochemical biosensors based on enzymes immobilized in electropolymerized films. Mikrochim Acta 121:167–181. Scholar
  87. Tung T, Castroa M, Pillin I et al (2014) Graphene–Fe3O4/PIL–PEDOT for the design of sensitive and stable quantum chemo-resistive VOC sensors. Carbon 74:104–112. Scholar
  88. Uemura T, Mamada M, Kumaki D, Tokito S (2013) Synthesis of semiconducting polymers through soluble precursor polymers with thermally removable groups and their application to organic transistors. ACS Macro Lett 2(9):830–833. Scholar
  89. Umana M, Waller J (1986) Protein-modified electrodes. The glucose oxidase/polypyrrole system. Anal Chem 58:2979–2983. Scholar
  90. Upadhyay PK, Ahmad A (2010) Chemical synthesis, spectral characterization and stability of some electrically conducting polymers. Chin J Polym Sci 28:191–197. Scholar
  91. Wan M (2009) Conducting polymers with micro or nanometer structure. Springer, BerlinGoogle Scholar
  92. Wang H, Yao S, Liu Y et al (2017) Molecularly imprinted electrochemical sensor based on Au nanoparticles in carboxylated multi-walled carbon nanotubes for sensitive determination of olaquindox in food and feedstuffs. Biosens Bioelectron 87:417–421. Scholar
  93. Wöll C (2009) Physical and chemical aspects of organic electronics. Wiley, WeinheimGoogle Scholar
  94. Xu J, Zhang Y, Wu K et al (2017) A molecularly imprinted polypyrrole for ultrasensitive voltammetric determination of glyphosate. Microchim Acta 184:1959–1967. Scholar
  95. Yu L, Zheng H, Shi M et al (2017) A novel electrochemical sensor based on poly(diallyldimethylammonium chloride)-dispersed graphene supported palladium nanoparticles for simultaneous determination of sunset yellow and tartrazine in soft drinks. Food Anal Methods 10:200–209. Scholar
  96. Zhang Y, Wang J, Xu M (2010) A sensitive DNA biosensor fabricated with gold nanoparticles/ploy (p-aminobenzoic acid)/carbon nanotubes modified electrode. Colloids Surf B 75:179–185. Scholar

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Authors and Affiliations

  • Constantin Apetrei
    • 1
  • Mateus D. Maximino
    • 2
  • Cibely S. Martin
    • 2
  • Priscila Alessio
    • 2
    Email author
  1. 1.Department of Chemistry, Physics, and Environment, Faculty of Sciences and Environment“Dunarea de Jos” University of GalatiGalatiRomania
  2. 2.School of Technology and Applied SciencesSão Paulo State University (UNESP)Presidente PrudenteBrazil

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