Sepsis and Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the 2016 Sepsis-3 consensus statement. The diagnosis of septic shock additionally requires hypotension despite adequate fluid resuscitation and high lactate. The diagnosis of sepsis requires both a suspected infection and signs of organ dysfunction. It is a very common cause of hospitalization and death. Management strategies include (1) early adequate antimicrobials, (2) aggressive resuscitation, (3) timely source control, (4) adjunctive therapies, and (5) appropriate de-escalation of therapies once the patient has stabilized.
KeywordsSepsis Septic shock Shock Antimicrobials Vasopressors Source control
- 17.The Arise Investigators and Anzics Clinical Trials Grou. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371:1496. https://doi.org/10.1056/NEJMoa1404380.
- 21.Parrillo JE, Dellinger RP. Critical care medicine: principles of diagnosis and management in the adult. 4th ed. Philadelphia: Elsevier; 2014.Google Scholar