Sepsis and Septic Shock

  • Anand Kumar
  • Victor Tremblay


Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the 2016 Sepsis-3 consensus statement. The diagnosis of septic shock additionally requires hypotension despite adequate fluid resuscitation and high lactate. The diagnosis of sepsis requires both a suspected infection and signs of organ dysfunction. It is a very common cause of hospitalization and death. Management strategies include (1) early adequate antimicrobials, (2) aggressive resuscitation, (3) timely source control, (4) adjunctive therapies, and (5) appropriate de-escalation of therapies once the patient has stabilized.


Sepsis Septic shock Shock Antimicrobials Vasopressors Source control 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Anand Kumar
    • 1
  • Victor Tremblay
    • 2
  1. 1.Section of Critical Care Medicine, Section of Infectious DiseasesUniversity of ManitobaWinnipegCanada
  2. 2.Section of Critical Care MedicineUniversity of ManitobaWinnipegCanada

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