Advertisement

Medical Work-Up of the Live Donor

  • Mats BrännströmEmail author
  • Pernilla Dahm-Kähler
Chapter

Abstract

The accumulated experience in live donor uterus transplantation is that the qualities of the uterus and the vasculature of the graft are critical factor for successful outcome of the transplantation procedure. Thus, the medical screening procedure to exclude possible cases with suboptimal donor organs is important for high success rate, in terms of transplantations that result in live births. This chapter reviews the current knowledge about several factors that have to be taken into account in screening for inclusion/exclusion of potential live donors. These factors include age, lifestyle factors, obstetric history, laboratory tests, cardiovascular examination, gynaecological examination and imaging modalities.

References

  1. Brännström M, Johannesson L, Dahm-Kähler P, et al. The first clinical uterus transplantation trial: a six months report. Fertil Steril. 2014;101:1228–36.CrossRefGoogle Scholar
  2. Brännström M, Johannesson L, Bokström H, et al. Live birth after uterus transplantation. Lancet. 2015;385:607–16.CrossRefGoogle Scholar
  3. Brucker SY, Brännström M, Taran FA, et al. Selecting living donors for uterus transplantation: lessons learned from two transplantations resulting in menstrual functionality and another attempt, aborted after organ retrieval. Arch Gynecol Obstet. 2018;297:675–84.CrossRefGoogle Scholar
  4. Chmel R, Novackova M, Janousek L, et al. Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: four deceased and five living donor uterus transplantations. Am J Transplant. 2019;19:855–64.CrossRefGoogle Scholar
  5. Ejzenberg D, Andraus W, BaratelliCarelli Mendes LR, et al. Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility. Lancet. 2019;392:2697–704.CrossRefGoogle Scholar
  6. Fageeh W, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. Int J Gynaecol Obstet. 2002;76:245–51.CrossRefGoogle Scholar
  7. Puntambekar S, Telang M, Kulkarni P, et al. Laparoscopic-assisted uterus retrieval from live organ donors of uterine transplant; our experience of two patients. J Minim Invasive Gynecol. 2018;25:622–31.CrossRefGoogle Scholar
  8. Puntambekar S, Puntambekar S, Telang M, et al. Novel anastomotic technique for uterine transplant using utero-ovarian veins for venous drainage and internal iliac arteries for perfusion in two laparoscopically harvested uteri. J Minim Invasive Gynecol. 2019;4:628–35.CrossRefGoogle Scholar
  9. Testa G, Koon EC, Johannesson L, et al. Living donor uterus transplantation: a single center’s observations and lessons learned from early setbacks to technical success. Am J Transplant. 2017;17:2901–10.CrossRefGoogle Scholar
  10. Wei L, Xue T, Tao KS, et al. Modified human uterus transplantation using ovarian veins for venous drainage: the first report of surgically successful robotic-assisted uterus procurement and follow-up for 12 months. Fertil Steril. 2017;108:346–56.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologySahlgrenska Academy, University of Gothenburg, Sahlgrenska University HospitalGothenburgSweden
  2. 2.Stockholm IVF-EUGINStockholmSweden

Personalised recommendations