Vagal Nerve Control of Appetite, Energy, Regulation, and Body Weight

  • Sachin Kukreja
  • Mark Knudson
  • Katherine Tweden
  • Kelly Aspinwall
  • Scott A. ShikoraEmail author


Obesity is a chronic, incurable disease that is also becoming a worldwide epidemic. While conventional bariatric surgical procedures are effective for achieving meaningful weight loss, these procedures are viewed by many candidates as being too dangerous or complicated. The vagus nerve has long been known to have a pivotal role in appetite and weight regulation. Previous studies have suggested that cutting the vagus nerve could result in weight loss. Reversible, programmable vagal blocking with an electrical pulse generator known as vBloc therapy has been shown to be an extremely safe modality that achieves meaningful and sustainable weight loss and improvements in the obesity-associated comorbid conditions. This chapter will review the physiology of the vagus nerve, the vBloc procedure, and the relevant preclinical and clinical studies.


Vagus nerve Vagus nerve blocking vBloc Obesity Weight loss Maestro rechargeable system 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sachin Kukreja
    • 1
  • Mark Knudson
    • 2
  • Katherine Tweden
    • 2
  • Kelly Aspinwall
    • 2
  • Scott A. Shikora
    • 3
    Email author
  1. 1.Minimally Invasive Surgical AssociatesDallasUSA
  2. 2.EnteroMedicsRosevilleUSA
  3. 3.Department of SurgeryBrigham and Women’s HospitalBostonUSA

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