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Vulnerability to Nontuberculous Mycobacterial Lung Disease or Systemic Infection Due to Genetic/Heritable Disorders

  • Edward D. Chan
Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

Nontuberculous mycobacteria (NTM) are ubiquitous in the natural and man-made environments, and yet human disease due to NTM is not widely pervasive. Presuming that human exposure to NTM is common, it suggests that NTM are relatively avirulent and that established infection resulting in disease occurs mostly in those who are innately susceptible. Most cases of NTM-LD and essentially all of extrapulmonary visceral/disseminated NTM disease occur in individuals with identifiable risk factors. While acquired disorders may predispose to either isolated NTM-LD or extrapulmonary visceral/disseminated NTM disease, this review focuses on genetic/heritable causes of these two forms of NTM disease.

Keywords

Nontuberculous mycobacteria Environmental mycobacteria Bronchiectasis Genetics Lung disease 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Pulmonary Section, Denver Veterans Affairs Medical CenterDenverUSA
  2. 2.Program in Cell Biology and Department of Academic Affairs, National Jewish HealthDenverUSA
  3. 3.Division of Pulmonary Sciences and Critical Care MedicineUniversity of Colorado Anschutz Medical CampusAuroraUSA

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