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Disease Caused by Mycobacterium Abscessus and Other Rapidly Growing Mycobacteria (RGM)

  • Julie V. Philley
  • David E. Griffith
Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

Rapidly growing mycobacteria (RGM) are divided into six major groups including the two clinically most important groups, M. chelonae/M. abscessus complex and Mycobacterium fortuitum group. This chapter discusses infections associated with these groups with an emphasis on pulmonary disease. Phenotypic and molecular laboratory identification methods are reviewed as accurate organism identification is necessary for optimal RGM lung disease patient management. Antimicrobial susceptibility patterns for the most common pathogenic RGM species are discussed with an emphasis on the impact of inducible macrolide resistance found in many RGM species and subspecies. Because of antibiotic resistance, the RGM are frequently difficult to treat successfully. Current therapeutic approaches are reviewed with an emphasis on antibiotic options in the context of both innate and acquired antibiotic resistance.

Keywords

Mycobacterium abscessus Rapidly growing mycobacteria Erm gene 

Notes

Acknowledgments

We humbly acknowledge and thank our patients with M. abscessus lung disease whose patience with their physicians, courage and strength are both boundless and inspirational.

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University of Texas Health Science CenterTylerUSA

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