Mechanisms of Cardiovascular Damage Induced by Traditional Chemotherapy

  • Valentina Mercurio
  • Giulio Agnetti
  • Pasquale Pagliaro
  • Carlo G. TocchettiEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Traditional chemotherapeutics are essential tools in the management of cancer patients. Nevertheless, these drugs are burdened by some degree of cardiovascular toxicity. Anthracycline-induced toxicity has been historically the most studied, but also the use of other drugs can be limited by a certain risk of cardiac and vascular toxicities. Here we acknowledge the main mechanistic insights, and we describe the different aspects of cardiotoxicity of these drugs, highlighting the different cellular compartments and cardiovascular components affected.


Chemotherapy Cardiovascular toxicity Cardiomyocytes Endothelial cells Oxidative stress 



CGT received speaking fees from Alere.


CGT is funded by a Federico II University/Ricerca di Ateneo grant.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Valentina Mercurio
    • 1
  • Giulio Agnetti
    • 2
    • 3
  • Pasquale Pagliaro
    • 4
  • Carlo G. Tocchetti
    • 5
    Email author
  1. 1.Division of Pulmonary and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.DIBINEMUniversity of BolognaBolognaItaly
  4. 4.Clinical and Biological SciencesAOU San Luigi GonzagaOrbassanoItaly
  5. 5.Department of Translational Medical SciencesFederico II UniversityNaplesItaly

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