Early Detection and Monitoring of Vascular Damage

  • Ciro Santoro
  • Roberta Esposito
  • Covadonga Fernández-Golfín
  • Jose Luis Zamorano Gomez
  • Maurizio GalderisiEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Vascular toxicity is one of the possible manifestations of anticancer-related cardiotoxicity in oncologic patients. Possible mechanisms of vascular toxicity include vasomotor, smooth muscle, and endothelial detrimental action on the vessels. Type II vascular dysfunction, which reflects coronary and peripheral vasospasm and finds relief in vasodilator therapies, requires careful attention in the acute phase. Conversely, type I vascular toxicity needs a well-planned, long-term follow-up. These different types of vascular damage can determine a broad spectrum of pathological conditions (arterial and venous thrombosis) which may become clinically overt in short-term periods or even appear progressively (peripheral vascular disease, stroke, coronary artery disease). Accordingly, vascular imaging tools shall be promoted for detecting early these manifestations and driving patient’s management. Accordingly, promptly detection of these possible adverse effects by vascular imaging should be strongly promoted to introduce efficient prophylactic therapies when indicated. It is fundamental to diagnose vascular complications and treat them aggressively in order to reduce deleterious adverse effects of anticancer therapy.


Anticancer drug Vascular toxicity Doppler echocardiography Vessels Coronary artery disease 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ciro Santoro
    • 1
  • Roberta Esposito
    • 1
  • Covadonga Fernández-Golfín
    • 2
  • Jose Luis Zamorano Gomez
    • 2
  • Maurizio Galderisi
    • 1
    Email author
  1. 1.Advanced Biomedical ScienceFederico II University HospitalNaplesItaly
  2. 2.Cardiology DepartmentRamon y Cajal University HospitalMadridSpain

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