Pulmonary Hypertension Induced by Anticancer Drugs

  • Valentina Mercurio
  • Giulio Agnetti
  • Pasquale Pagliaro
  • Carlo G. TocchettiEmail author
Part of the Current Clinical Pathology book series (CCPATH)


Pulmonary vascular damage is a rare but possible complication of treatment with chemotherapeutic agents or bone marrow transplantation. The main clinical manifestations involving the pulmonary vessels are the development of pulmonary arterial hypertension or pulmonary veno-occlusive disease. In this chapter we describe the main mechanisms underlying the development of this form of toxicity, the screening algorithm, and its clinical management.


Pulmonary hypertension Pulmonary veno-occlusive disease Bone marrow transplantation Alkylating agents Mitomycin C and bleomycin Tyrosine kinase inhibitor Dasatinib 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Valentina Mercurio
    • 1
  • Giulio Agnetti
    • 2
    • 3
  • Pasquale Pagliaro
    • 4
  • Carlo G. Tocchetti
    • 5
    Email author
  1. 1.Division of Pulmonary and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.DIBINEMUniversity of BolognaBolognaItaly
  4. 4.Clinical and Biological SciencesAOU San Luigi GonzagaOrbassanoItaly
  5. 5.Department of Translational Medical Sciences, Federico II UniversityNaplesItaly

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