Advertisement

Infiltrating Carcinoma of No Special Type

  • Simona Stolnicu
Chapter

Abstract

Infiltrating breast carcinoma is a category of malignant epithelial tumors characterized by adjacent tissue invasion and distance metastasis. This category includes several microscopic types that differ from one another from morphological, immunohistochemical, molecular, and prognostic points of view. It is currently known that all these microscopic types have their origin in the terminal duct/lobular unit. The WHO 2012 classification categorized both invasive carcinomas of no special type (NST), previously termed as ductal carcinomas, and lobular and other special and rare subtypes of carcinomas, as infiltrating epithelial tumors, only distinguishing between these types in terms of morphological appearance, but disregarding the origin of proliferation [1].

Keywords

Morphology Ductal differentiation Immunohistochemical stains Differential diagnosis 

References

  1. 1.
    Lakhani SR, Schnitt SJ, Tan PH, van deVijver MJ. WHO classification of tumors of the breast. Lyon: IARC; 2012.Google Scholar
  2. 2.
    Tavassoli FA. Pathology of the breast. 2nd ed. New York, NY: McGraw-Hill; 1999.Google Scholar
  3. 3.
    Moinfar F. Essentials of diagnostic breast pathology. Berlin: Springer; 2007. p. 236.Google Scholar
  4. 4.
    Leibl S, Gogg-Kammerer M, Sommersacher A, Denk H, Moinfar F. Metaplastic breast carcinoma: are they of myoepithelial differentiation? Immunohistochemical profile of the sarcomatoid subtype using novel myoepithelial markers. Am J Surg Pathol. 2005;29:347–53.CrossRefPubMedGoogle Scholar
  5. 5.
    Pettinato G, Petrella G, Manco A, di Prisco B, Salvatore G, Angrisani P. Carcinoma of the breast with osteoclast-like giant cells. Fine-needle aspiration cytology, histology and electron microscopy of 5 cases. Appl Pathol. 1984;2(3):168–78.PubMedGoogle Scholar
  6. 6.
    Saigo PE, Rosen PP. Mammary carcinoma with choriocarcinomatous features. Am J Surg Pathol. 1981;5(8):773–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Resetkova E, Sahin A, Ayala AG, Sneige N. Breast carcinoma with choriocarcinomatous features. Ann Diagn Pathol. 2004;8(2):74–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Zhu Y, Liu M, Li J, Jung F, Linghu R, Guo X, et al. Breast carcinoma with choriocarcinomatous features: a case report and review of the literature. World J Surg Oncol. 2014;12:239.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Simona Stolnicu
    • 1
  1. 1.Department of PathologyUniversity of Medicine and PharmacyTîrgu MureșRomania

Personalised recommendations