The Life and the Major Scientific Contributions of Irvine Page

  • Emmanuel A. Andreadis
  • Charalampia V. Geladari


Dr. Irvine Heinly Page is one of the hypertension pioneer researchers, whose work has been a landmark for understanding the mechanisms related to this devastating condition. Among his most important scientific contributions in the field are the identification of the renin angiotensin system, the identification of serotonin, the description of a neurogenic mechanism in renal hypertension, baroreceptor resetting, and of course, the widely acknowledged mosaic theory of hypertension. In this chapter we discuss milestone moments in his life and scientific career, and we aim to offer to young scientists engaged in the cardiovascular field an insight into the personality and abilities of this great man, physician and researcher.


Hypertension Pioneer researcher Irvine page Renin angiotensin system Mosaic theory 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Emmanuel A. Andreadis
    • 1
    • 2
  • Charalampia V. Geladari
    • 2
    • 3
  1. 1.Hypertension and Cardiovascular Disease Prevention Center, Evangelismos General HospitalAthensGreece
  2. 2.Fourth Internal Medicine DepartmentEvangelismos State General HospitalAthensGreece
  3. 3.Department of Medicine, Division of CardiologyBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA

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