Benzodiazepines and Z-Drugs During Lactation
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Lactating women may experience psychiatric disturbances such as depression, anxiety, and insomnia, which require benzodiazepines or Z-drugs for treatment. The most important aspect of treatment during the lactation period is to achieve balance between improvement of maternal psychiatric symptoms and safety of breastfed infants. If the decision to administer a benzodiazepine is made, lorazepam appears to be the most preferable agent with respect to the safety of infants. Limited available data suggest that zaleplon, zopiclone, and zolpidem may be compatible with breastfeeding. These medications should be used at as low doses as possible and for a short time. Moreover, the infants exposed to these drugs via breast milk should be carefully monitored.
KeywordsBenzodiazepine Z-drugs Breastfeeding Lactation
- 3.Wilt TJ, MacDonald R, Brasure M, Olson CM, Carlyle M, Fuchs E, Khawaja IS, Diem S, Koffel E, Quelette J, Butler M, Kane RL. Pharmacologic treatment of insomnia disorder: an evidence report for a clinical practice guideline by American College of Physicians. Ann Intern Med. 2016;165:103–12.CrossRefGoogle Scholar
- 11.Orsolini L, Valchera A, Bellantuono C. Antidepressants and anxiolytics during lactation. In: Uguz F, editor. Psychiatric disorders during the postpartum period in light of current advances. New York, NY: Nova Science Publishers, Inc.; 2016. p. 115–42.Google Scholar
- 18.Uguz F. Breastfeeding and psychotropic medications. In: Uguz F, editor. Psychotropic drugs and medical conditions. New York, NY: Nova Science Publishers Inc.; 2017. p. 209–29.Google Scholar