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Operative Management Versus Observation for Thyroid Nodules Larger than 4 cm with Benign Cytology

  • Nicole A. Cipriani
Chapter
Part of the Difficult Decisions in Surgery: An Evidence-Based Approach book series (DDSURGERY)

Abstract

Workup of thyroid nodules usually involves a multi-disciplinary approach, including fine needle aspiration (FNA) biopsy. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was devised to stratify patients into tiers with increasing risk for cancer, based on features identified on FNA. A number of studies have attempted to correlate thyroid nodule size with intrinsic risk of malignancy, as well as with false negative rates (nodules with a benign diagnosis on cytology but a malignant diagnosis on final surgical pathology following resection). The aims of this chapter are (1) to review studies that have evaluated the false negative rate of thyroid nodules based on size, (2) to summarize, analyze, and grade the published data, and (3) to make recommendations for treatment of large thyroid nodules.

Keywords

Fine-needle aspiration (FNA) Ultrasonography Thyroid nodules False negative rates 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The University of Chicago, Department of PathologyChicagoUSA

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