The use of RT for pancreatic cancer is controversial. Though RT increases local control, this has not usually translated to an OS benefit, likely due to the high competing risk of distant metastases. Selection of appropriate candidates for RT is therefore challenging. The use of hypofractionated techniques such as SBRT has been investigated to potentially increase local control, to increase resectability, and to decrease the overall treatment time, minimizing patient burden and delay of systemic therapy. In this chapter, we will review the use of SBRT for pancreatic malignancies.
KeywordsPancreas cancer SBRT Borderline resectable Locally advanced Duodenum