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Hepatobiliary Malignancies

  • Kyle Wang
  • Andrew Z. Wang
  • Joel E. Tepper
Chapter

Abstract

Historically, the radiosensitivity of hepatocytes and risk for radiation-induced liver disease (RILD) precluded the use of RT for liver tumors using older techniques. CT-based planning, SBRT, and IMRT have generated renewed interest in the treatment of liver malignancies due to the new ability to deliver high doses to tumors with good normal tissue sparing. Though surgery is the primary treatment modality for liver tumors, RT provides previously unavailable opportunities for durable local control in patients who are inoperable or not candidates for other ablative approaches. Here, we review hypofractionated RT (focusing on SBRT) for hepatocellular carcinoma (HCC), cholangiocarcinoma (predominantly intrahepatic and perihilar types), and liver metastases. Though distinct clinical entities, the principles of SBRT delivery are similar, though cirrhosis commonly impacts dose delivery in patients with HCC.

Keywords

Liver Bile duct Hepatocellular carcinoma Cholangiocarcinoma Liver metastases SBRT 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Kyle Wang
    • 1
  • Andrew Z. Wang
    • 1
  • Joel E. Tepper
    • 1
  1. 1.Department of Radiation OncologyUniversity of North Carolina HospitalsChapel HillUSA

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