Advertisement

Re-irradiation

  • Gregory D. Judy
  • Bhishamjit S. Chera
Chapter

Abstract

There is a growing body of literature using SBRT in the re-irradiation setting for locally recurrent H&N tumors. Doses vary, with best results/lowest toxicity ≥35 Gy in five fractions, given on alternating days. Toxicity rates of SBRT appear to be lower than with conventional techniques; however severe acute and late toxicities remain a challenge.

Keywords

Head and neck Re-irradiation SBRT Toxicity 

References

  1. 1.
    Vargo JA, Ferris RL, Ohr J, et al. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2015;91:480–8.CrossRefPubMedGoogle Scholar
  2. 2.
    Comet B, Kramar A, Faivre-Pierret M, et al. Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study. Int J Radiat Oncol Biol Phys. 2012;84:203–9.CrossRefPubMedGoogle Scholar
  3. 3.
    Vargo JA, Wegner RE, Heron DE, et al. Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck. Head Neck. 2012;34:1153–61.CrossRefPubMedGoogle Scholar
  4. 4.
    Heron DE, Ferris RL, Karamouzis M, et al. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys. 2009;75:1493–500.CrossRefPubMedGoogle Scholar
  5. 5.
    Ling DC, Vargo JA, Heron DE. Stereotactic body radiation therapy for recurrent head and neck cancer. Cancer J. 2016;22:302–6.CrossRefPubMedGoogle Scholar
  6. 6.
    Ling DC, Vargo JA, Ferris RL, et al. Risk of severe toxicity according to site of recurrence in patients treated with stereotactic body radiation therapy for recurrent head and neck cancer. Int J Radiat Oncol Biol Phys. 2016;95:973–80.CrossRefPubMedGoogle Scholar
  7. 7.
    Owen D, Iqbal F, Pollock BE, et al. Long-term follow-up of stereotactic radiosurgery for head and neck malignancies. Head Neck. 2015;37:1557–62.CrossRefPubMedGoogle Scholar
  8. 8.
    Rwigema JC, Heron DE, Ferris RL, et al. The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy. Am J Clin Oncol. 2011;34:372–9.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Gregory D. Judy
    • 1
    • 2
  • Bhishamjit S. Chera
    • 1
    • 2
  1. 1.Department of Radiation OncologyUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Lineberger Comprehensive Cancer CenterUniversity of North Carolina School of MedicineChapel HillUSA

Personalised recommendations