How to Induce Arrhythmias with Atropine

  • Calin Siliste
  • Roxana-Nicoleta Siliste


Atropine sulfate is the sulfate salt of atropine, which is an alkaloid found in its natural form together with scopolamine and hyoscyamine in the plant Atropa belladonna. The first synthesis of atropine was achieved by Richard Willstätter, a German organic chemist whose studies in the field of alkaloids brought him the 1915 Nobel Prize for Chemistry. Usual doses of atropine (>0.5 mg) abolish various types of vagal reflexmediated bradycardia or asystole and also prevent or abolish the negative chronotropic effect produced by other parasympathomimetic drugs. Atropine also ameliorates the AV conduction when an incomplete block is noted. In some patients with complete heart block, the resultant escape rhythm rate (junctional origin) may be accelerated by atropine.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Calin Siliste
    • 1
  • Roxana-Nicoleta Siliste
    • 2
  1. 1.Cardiology Department, University Emergency HospitalUniversity of Medicine and Pharmacy “Carol Davila”BucharestRomania
  2. 2.Internal Medicine and Cardiology DepartmentColtea Clinical Hospital, University of Medicine and Pharmacy “Carol Davila”BucharestRomania

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