How to Induce Arrhythmias with Isoprenaline
- 354 Downloads
Isoprenaline is an analog of epinephrine with a pure β1 and β2 effect. It is the isopropylamine of epinephrine and acts nonselectively on beta-receptors from the heart, bronchi, skeletal muscle, and alimentary tract. It is used for its bronchodilator and positive chronotropic effect. It was used in asthma, but at the moment there are other β2 selective agonists that are preferred. In the 1930s, isoprenaline was used as a vasoconstrictor and decongestant. Later it was injected during anesthesia because it could maintain the blood pressure without reduction of the perfusion into the vital organs.
- 8.Osborne BE. Uses and applications of electrocardiography in toxicology. Proc Eur Soc Study Drug Toxic. 1974;15:85.Google Scholar
- 19.Naccarelli G, Berns E, Dougherty A, Jenkins M, Rinkenberger R. Isoproterenol reversal of encainide effect in the Wolf-Parkinson-White syndrome. PACE. 1987;10:95–100.Google Scholar
- 22.Helmy I, Scheinman MM, Sharkey H, Herre JM, Griffin JC. Isoproterenol reversal of flecainide effects in patients with accessory pathways. Circulation. 1987;76(suppl IV):IV–69.Google Scholar
- 25.Wellens HJ, Duren DR, Liem KL, Lie KI. Effect of digitalis in patients with paroxysmal atrial ventricular nodal tachycardia. Circulation. 1975;52:77–88.Google Scholar