How to Induce Arrhythmias with Aminophylline?
- 314 Downloads
Aminophylline, a methylxanthine, is a 2:1 combination between theophylline and ethylenediamine. The 2:1 ratio improves the solubility of the product. Compared to theophylline, aminophylline is a less potent nonselective adenosine receptor antagonist and phosphodiesterase inhibitor. The effects on the sinus node are reduction in the corrected sinus node recovery time and sinoatrial conduction time. The effect on the atrial tissue is reduction in the atrial refractory period. The effect on the AV node was decrease in the Wenckebach point and AH time. The effect on the His-Purkinje system is reduction in the HV conduction time. There was no change in the ventricular refractory period.
- 3.Hurley KF, Magee K, Green R. Aminophylline for bradyasystolic cardiac arrest in adults. Cochrane Database Syst Rev. 2013;(8):CD006781.Google Scholar
- 5.Ostapiuk M, et al. [Effect of aminophylline on electrophysiological characteristics of the accessory pathway in patients with Wolff-Parkinson-White syndrome]. Kardiol Pol. 1988;31(3):173–9.Google Scholar
- 9.Molenda W, et al. [Effect of aminophylline on the heart conduction system in patients with paroxysmal nodal tachycardia]. Kardiol Pol. 1988;31(2):84–90.Google Scholar
- 10.Molenda W, et al. [Effect of aminophylline on the ventricular part of the heart conduction system]. Pol Arch Med Wewn. 1988;79(5):256–62.Google Scholar
- 11.Molenda W, et al. Effect of aminophylline on the heart conduction system in patients with concealed accessory atrioventricular node bypass. Pol Tyg Lek. 1987;42(10):287–90.Google Scholar
- 14.Montenero AS, et al. [Electrophysiologic and hemodynamic effects of intravenous aminophylline in humans]. Cardiologia. 1987;32(9):1005–7.Google Scholar
- 28.Telichowski C, et al. [Effect of aminophylline on the occurrence of reciprocal tachycardia in patients with Wolff-Parkinson-White syndrome]. Wiad Lek. 1987;40(19):1353–7.Google Scholar
- 30.Aliot EM, et al. EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA). Heart Rhythm. 2009;6(6):886–933.CrossRefGoogle Scholar