How to Induce Arrhythmias with Salbutamol
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Salbutamol is a selective beta2 adrenoreceptor agonist causing bronchodilation. It is commonly used for the treatment of acute bronchoconstriction episodes such as acute asthmatic crisis or status asthmaticus. It is also used for treatment of chronic obstructive pulmonary disease. As a β2 selective agonist, intravenous salbutamol may also serve as a pharmacologic agent for the induction of arrhythmias during electrophysiological study (EPS). Infusion of salbutamol significantly shortens sinus node cycle length and sinus node recovery time. It also shortens effective refractory period of the AV node, significantly shortens AH interval and the Wenckebach point (WP), and decreases atrial and ventricular effective refractory periods. Doses used in the setting of EPS differ from those used during acute asthmatic crisis. A recommended single bolus dose for use in the EP lab equals 0.125 mg of salbutamol.
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