Drug-Coated Balloon in Superficial Femoral Artery In-Stent Restenosis

  • Donato Gerardi
  • Arturo Alfani
  • Giovanni Esposito
  • Eugenio Stabile


Although the widespread use of new-generation, self-expanding, nitinol stents in superficial femoral artery (SFA) stenosis has reduced the shortcomings associated with a plain old balloon angioplasty (POBA) for SFA, lumen renarrowing at the stented level (in-stent restenosis, ISR) represents a relevant clinical problem.

Several endovascular approach have been attempted to treat ISR (i.e., POBA, debulking, use of covered stents) but, as of today, none of this have been proved to be effective.

In this review we examine the results of different trials exploring the outcome of using drug-coated balloons (DCBs) for the treatment of SFA ISR.

The consistent and positive results of different registries and randomized trials support the concept that the use of DCB is associated with a reduction in recurrent restenosis and target lesion revascularization (TLR) at least at 1 year after plain old balloon angioplasty (POBA). The available data strongly support the use of DCB to reduce SFA ISR recurrence.





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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Donato Gerardi
    • 1
  • Arturo Alfani
    • 1
  • Giovanni Esposito
    • 1
  • Eugenio Stabile
    • 1
  1. 1.Division of Cardiology, Department of Advanced Biomedical Sciences“Federico II” UniversityNapoliItaly

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