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Lessons from Rodent Models for Genetic and Age-Related Hearing Loss

  • Kevin K. Ohlemiller
Chapter
Part of the Springer Handbook of Auditory Research book series (SHAR, volume 67)

Abstract

This chapter compares the six most heavily studied rodent models with regard to hearing-in-aging and the availability of mutant lines that recapitulate human genetic hearing loss. Four of the six models are available only as outbreds, and much of that work has been based on genetically nonstandard animals of unclear origin. Some of these (guinea pigs and chinchillas) may no longer resemble their wild counterparts. Some results from outbred models may not be reproducible, since it may be impossible for experimenters to know if they are testing the same genetic models. Likewise, engineered or induced mutations onto outbred lines may not be productive because characterization can be confounded by variable and unknown modifier genes. Naturally arising coat color-related mutations may influence hearing through an absence of melanin or melanocytes. These lines may not be commercially available, however. Hamsters are not well described with respect to detailed hearing or aging studies. Gerbils, guinea pigs, and chinchillas are well explored both as general hearing models and as aging models. Inbred mice and rats have become the primary models for most research over the last 20 years. Inbred models offer a high degree of genetic standardization and reproducibility of results. Their short lifespans and the availability of lines with progressive hearing loss have made mice and rats popular for aging research. They also foster transgenic methods and gene discovery, but mice and rats may not be optimal for studies that require low-frequency hearing or readily accessible inner ear fluid spaces.

Keywords

Auditory neuron Chinchilla Cochlea Endocochlear potential Gerbil Guinea pig Hair cells Hamster Inbred stock Mouse Mutation Outbred stock Presbycusis Rat Stria vascularis 

Notes

Compliance with Ethics Requirements

Kevin Ohlemiller declares that he has no conflict of interest.

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Authors and Affiliations

  1. 1.Fay and Carl Simons Center for Biology of Hearing and Deafness, Central Institute for the Deaf at Washington UniversitySaint LouisUSA
  2. 2.Department of OtolaryngologyWashington University, School of MedicineSaint LouisUSA

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