Advertisement

Coagulation System

  • Dietrich Klauwer
Chapter

Abstract

This chapter recapitulates the coagulation process and describes common agents that exert an effect on coagulation while discussing routine anticoagulation post-CPB surgery. This includes a discussion of the causes and treatment of bleeding and hypercoagulability. The most common coagulation problems associated with postoperative pediatric heart surgery are concisely outlined.

Suggested Reading

  1. 1.
    Berlot G. Hemocoagulative problems in the critically ill patient. Heidelberg: Springer; 2012.CrossRefGoogle Scholar
  2. 2.
    Blanchette VS, et al. SickKids handbook of pediatric thrombosis and hemostasis. 1st ed. Basel: Karger; 2013.CrossRefGoogle Scholar
  3. 3.
    Eaton MP, Iannoli EM. Coagulation considerations for infants undergoing cardiopulmonary bypass. Pediatr Anesth. 2011;21:31–42.CrossRefGoogle Scholar
  4. 4.
    Ehrenforth S, et al. Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Eur J Pediatr. 1999;58:S97–S104.CrossRefGoogle Scholar
  5. 5.
    Grassin-Delyle S, et al. A practical tranexamic acid dosing scheme based on population pharmacokinetics in children undergoing cardiac surgery. Anesthesiology. 2013;118:853–62.CrossRefGoogle Scholar
  6. 6.
    Monagle P, et al. Antithrombotic therapy in neonates and children antithrombotic therapy and prevention of thrombosis. 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2004;126(3 Suppl):645S–87S. Review.Google Scholar
  7. 7.
    Nichols D, editor. Roger’s textbook of pediatric intensive care. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wolkins; 2008.Google Scholar
  8. 8.
    Weber CF, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012;117(9):531–47.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Dietrich Klauwer
    • 1
  1. 1.Department of PediatricsSingen Medical Center, Gesundheitsverbund Landkreis Konstanz,Krankenhausbetriebsgesellschaft Hegau-Bodensee-KlinikumSingenGermany

Personalised recommendations