Clinical Signs

  • Shawn Babiuk


The clinical signs caused by the lumpy skin disease virus (LSDV) are highly variable in the severity of disease in both natural outbreaks and in experimental inoculation of cattle. Clinical disease can range from unapparent, mild or moderate to severe form. The factors affecting the wide range of disease are likely to be complex and multifactorial, including the dose of virus inoculate, genetic factors of the host and the virus as well as the immune competence and possibly the age of the host with some studies demonstrating younger animals being more susceptible. With sheeppox and goatpox, younger animals are more susceptible. Clinical signs caused by LSDV were demonstrated to be much more severe in high-producing dairy breeds such as Holstein Friesian cattle compared to indigenous breeds (Davies 1991; Tageldin et al. 2014).


  1. Ahmed WM, Zaher KS (2008) Observations on lumpy skin disease in local Egyptian cows with emphasis on its impact on ovarian function. Afr J Microbiol Res 2:252–257Google Scholar
  2. Annandale CH, Irons PC, Bagla VP, Osuagwuh UI, Venter EH (2010) Sites of persistence of lumpy skin disease virus in the genital tract of experimentally infected bulls. Reprod Domest Anim 45:250–255CrossRefPubMedGoogle Scholar
  3. Davies FG (1991) Lumpy skin disease, an African capripox virus disease of cattle. Br Vet J 147:489–503CrossRefPubMedGoogle Scholar
  4. Neamat-Allah AN (2015) Immunological, hematological, biochemical, and histopathological studies on cows naturally infected with lumpy skin disease. Vet World 8:1131–1136CrossRefPubMedPubMedCentralGoogle Scholar
  5. Rouby S, Aboulsoud E (2016) Evidence of intrauterine transmission of lumpy skin disease virus. Vet J 209:193–195CrossRefPubMedGoogle Scholar
  6. Şevik M, Avci O, Doğan M, İnce ÖB (2016) Serum biochemistry of lumpy skin disease virus-infected cattle. Biomed Res Int 2016:6257984CrossRefPubMedPubMedCentralGoogle Scholar
  7. Tageldin MH, Wallace DB, Gerdes GH, Putterill JF, Greyling RR, Phosiwa MN, Al Busaidy RM, Al Ismaaily SI (2014) Lumpy skin disease of cattle: an emerging problem in the Sultanate of Oman. Trop Anim Health Prod 46:241–246CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shawn Babiuk
    • 1
    • 2
  1. 1.Canadian Food Inspection Agency, National Centre for Foreign Animal DiseaseWinnipegCanada
  2. 2.University of ManitobaWinnipegCanada

Personalised recommendations