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Vitamins, Nutraceuticals, Food Additives, Enzymes, Anesthetic Aids, and Cosmetics

  • A. N. M. Alamgir
Chapter
Part of the Progress in Drug Research book series (PDR, volume 74)

Abstract

Vitamins are low-molecular-weight organic compounds, indispensable for life activity in trace amounts for essential metabolic reactions, where deficiency causes specific disease symptom and do not include other essential nutrients such as dietary minerals, essential fatty acids, or essential amino acids, nor does it encompass the large number of other nutrients that promote health and do not provide cellular structural material and energy. Animals derived vitamins from plants and microorganisms. Vitaminoids are compounds with “vitamin-like” activity. Vitamins fall into two main groups: fat-soluble (e.g., A, D, E) and water-soluble (e.g., B, C, P) vitamins. Nutraceuticals include a number of substances ranging from natural diets, herbal products, biofortified crops, genetically modified, and processed food products. Nutraceuticals beyond basic nutrition provide health benefit, modulate immunity, and/or prevent and cure specific diseases. Functional foods are whole, fortified, enriched, or enhanced foods that provide health benefits beyond the provision of essential nutrients and classified into several groups on the basis of food group, the diseases it prevents or alleviates, physiological effects, etc. Food additives are antioxidants, food preservatives, food coloring agents, flavoring agents, anti-infective agents, excipients, and other similar substances used in the processing or storage of foods or animal feed. Excipients have little or no therapeutic value, but contribute largely to the performance of the active pharmaceutical ingredient (API) and maintain the quality, efficacy, safety, etc., of the formulation and include solvents, diluting, suspending, and emulsifying agents as well as antioxidants, preservatives, pharmaceutical, coloring agents, flavoring agents, vehicles, excipients, ointment bases, etc. Proteins and peptides allow the development of antibodies and different fermentations, purification processes, and recombination technology produced potential protein drugs at acceptable cost which can be useful in various diseases through various routes like oral, transdermal, nasal, pulmonary, ocular, buccal, and rectal. Many protein pharmaceuticals are available for treating rheumatoid arthritis, coronary artery thrombosis, multiple sclerosis, and chronic lymphocytic leukemia. Papain, a plant enzyme, is very helpful for the prevention of atherosclerosis and diabetic heart disease. Natural anesthetics, e.g., cocaine, methyl salicylate, capsaicin, piperine, opium, etc., have been in use since antiquity. Cosmeceuticals are cosmetic-pharmaceutical hybrid products intended to improve the health and beauty of the skin by providing a specific result, ranging from acne-control and anti-wrinkle effects to sun protection.

Keywords

Vitamins Nutraceuticals Food additives Enzymes Anesthetic aids Cosmeceuticals 

References

  1. Abdullaev Jafarova F, Caballero-Ortega H, Riverón-Negrete L, Pereda-Miranda R, Rivera-Luna R, Manuel Hernández J et al (2002) In vitro evaluation of the chemopreventive potential of saffron. Rev Invest Clin 54(5):430–436PubMedPubMedCentralGoogle Scholar
  2. Aberg F, Appelkvist EL, Dallner G, Ernster L (1992) Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 295(2):230–234PubMedCrossRefPubMedCentralGoogle Scholar
  3. Akhtari K, Hassanzadeh K, Fakhraei B, Fakhraei N, Hassanzadeh H, Zarei SA (2013) A density functional theory study of the reactivity descriptors and antioxidant behavior of crocin. Comput Theor Chem 1013:123–129CrossRefGoogle Scholar
  4. Ali B, Ali N, Wabel A, Shams S, Ahamad A, Khan SA, Anwar F (2015) Essential oils used in aromatherapy: a systemic review. Asian Pacific J Tropical Biomed 5(8):601–611CrossRefGoogle Scholar
  5. Allen MA, Burgess SG (1950) The losses of ascorbic acid during the large-scale cooking of green vegetables by different methods. Br J Nutr 4(2–3):95–100PubMedCrossRefPubMedCentralGoogle Scholar
  6. Allgeyer LC, Miller MJ, Lee SY (2010) Sensory and microbiological quality of yogurt drinks with prebiotics and probiotics. J Dairy Sci 93:4471–4479PubMedCrossRefPubMedCentralGoogle Scholar
  7. Aluru M, Xu Y, Guo R, Wang Z, Li S, White W et al (2008) Generation of transgenic maize with enhanced provitamin A content. J Exp Bot 59:3551–3562PubMedPubMedCentralCrossRefGoogle Scholar
  8. Anonymous (1973) Committee on Food Protection; Food and Nutrition Board; National Research Council (1973) Phytates. Toxicants occurring naturally in foods. National Academy of Sciences, pp 363–371Google Scholar
  9. Anonymous (1998) Dietary supplement fact sheet: Folate. Health Information. Office of Dietary Supplements, US National Institutes of HealthGoogle Scholar
  10. Anonymous (2000) Dietary reference intakes: vitamin C, vitamin E, selenium, and carotenoids. Institute of Medicine, Food and Nutrition Board, National Academy Press, Washington.  https://doi.org/10.17226/9810
  11. Anonymous (2004) Chambers Concise Dictionary. Allied Publishers. 2004. p. 451Google Scholar
  12. Anonymous (2005) Collins dictionary of biology, 3rd edn. © W. G. Hale, V. A. Saunders, J. P. MarghamGoogle Scholar
  13. Anonymous (2017) USDA database for the flavonoid content of selected foods. https://www.ars.usda.gov/SP2UserFiles/Place/12354500/Data/Flav/Flav_R03.pdf
  14. Anthony JB, Harriet CB, Matti J, Dean JT (1993) Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res 17(3):552–555CrossRefGoogle Scholar
  15. Ayoub M, de Camargo AC, Shahidi F (2016) Antioxidants and bioactivities of free, esterified and insoluble-bound phenolics from berry seed meals. Food Chemistry 197(Part A):221–232PubMedCrossRefPubMedCentralGoogle Scholar
  16. Banerjee R (2007) Redox biochemistry. Wiley, New York, p. 35Google Scholar
  17. Becerra-Moreno A, Alanís-Garza P, Mora-Nieves JL, Mora-Mora JP, Jacobo-Velázquez DA (2014) Kale: an excellent source of vitamin C, pro-vitamin A, lutein and glucosinolates. CyTA-J Food 12:298–330CrossRefGoogle Scholar
  18. Beck K, Conlon CA, Kruger R, Coad J, Stonehouse W (2011) Gold kiwifruit consumed with an iron-fortified breakfast cereal meal improves iron status in women with low iron stores: a 16-week randomized controlled trial. Br J Nutr 105:101–109PubMedCrossRefPubMedCentralGoogle Scholar
  19. Bender DA, Bender AE (2005) A dictionary of food and nutrition. Oxford University Press, New YorkGoogle Scholar
  20. Bieri JG, Evarts RP, Evarts (1974) γ-Tocopherol: metabolism, biological activity and significance in human vitamin E nutrition. Am J Clin Nutrition 27(9):980–986Google Scholar
  21. Biewenga GP, Haenen GR, Bast A (1997) The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 29(3):315–331PubMedCrossRefPubMedCentralGoogle Scholar
  22. Birt DF, Hendrich S, Wang W (2001) Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90(2–3):157–177PubMedCrossRefPubMedCentralGoogle Scholar
  23. Block G, Patterson B, Subar A (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18:1–29PubMedCrossRefPubMedCentralGoogle Scholar
  24. Bourgis F (1999) S-methylmethionine plays a major role in phloem sulfur transport and is synthesized by a novel type of methyltransferase. Plant Cell 11(8):1485–1498PubMedPubMedCentralCrossRefGoogle Scholar
  25. Bracco P, Oral E (2011) Vitamin E-stabilized UHMWPE for total joint implants: A review. Clin Orthop Relat Res 469(8):2286–2293PubMedCrossRefPubMedCentralGoogle Scholar
  26. Bremer J (1983) Carnitine–metabolism and functions. Physiol Rev 63(4):1420–1480PubMedCrossRefPubMedCentralGoogle Scholar
  27. Brigelius-Flohé R, Traber MG (1999) Vitamin E: function and metabolism. FASEB J. 13(10):1145–1155PubMedCrossRefPubMedCentralGoogle Scholar
  28. Brody T (1999) Nutritional biochemistry, 2nd edn. Academic Press, San Diego, 1999Google Scholar
  29. Bruckert E, Labreuche J, Amarenco P (2010) Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 210(2):353–361PubMedCrossRefPubMedCentralGoogle Scholar
  30. Burke KE (2007) Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther 20(5):314–321PubMedCrossRefPubMedCentralGoogle Scholar
  31. Carmel R (2006) Cobalamin (Vitamin B-12). In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ (eds) Modern nutrition in health and disease. Lippincott Williams & Wilkins, Philadelphia, pp 482–497Google Scholar
  32. Cayen MN, Dvornik D (1979) Effect of diosgenin on lipid metabolism in rats. J Lipid Res 20(2):162–174PubMedPubMedCentralGoogle Scholar
  33. Chakraborty S, Chakraborty N, Agrawal L, Ghosh S, Narula K, Shekhar S et al (2010) Next-generation protein-rich potato expressing the seed protein gene AmA1 is a result of proteome rebalancing in transgenic tuber. Proc Natl Acad Sci USA 107:17533–17538CrossRefGoogle Scholar
  34. Charalampopoulos D, Wang R, Pandiella SS, Webb C (2002) Application of cereals and cereal components in functional foods: a review. Int J Food Microbiol 79:131–141PubMedCrossRefPubMedCentralGoogle Scholar
  35. Chaudhari SP, Tam AY, Barr JA (2015) Curcumin: a contact allergen. J Clin Aesthet Dermatol 8(11):43–48PubMedPubMedCentralGoogle Scholar
  36. Chauhan B, Kumar G, Kalam N, Ansari SH (2013) Current concepts and prospects of herbal nutraceutical: a review. J Adv Pharm Technol Res 4(1): 4–8. doi:  10.4103/2231-4040.107494CrossRefGoogle Scholar
  37. Cheney G (1950) Anti-peptic ulcer dietary factor (vitamin ‘U’) in the treatment of peptic ulcer. J Am Diet Assoc 26(9):668–672PubMedPubMedCentralGoogle Scholar
  38. Chow J, Klein EY, Laxminarayan R (2010) Cost-effectiveness of golden mustard for treating vitamin A deficiency in India. PLoS ONE 5(8):e12046PubMedPubMedCentralCrossRefGoogle Scholar
  39. Chryssanthi DG, Lamari FN, Iatrou G, Pylara A, Karamanos NK, Cordopatis P (2007) Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res 27(1A):357–362PubMedPubMedCentralGoogle Scholar
  40. Combs GF (2001). The vitamins, fundamental aspects in nutrition and health, 2nd edn. Academic Press, San Diego, pp 245–272Google Scholar
  41. Combs GF Jr (2008) The vitamins: fundamental aspects in nutrition and health, 3rd edn. Elsevier, Ithaca. ISBN 978-0-12-183493-7Google Scholar
  42. Darby WJ, Jones E (1945) Treatment of sprue with synthetic L. casei factor (folic acid, vitamin M). Experim Biol Med 60(2):259–262CrossRefGoogle Scholar
  43. De Nicola R, Bagatta M, Pagnotta E, Angelino D, Gennari L et al (2014) Comparison of bioactive phytochemical content and release of isothiocyanates in selected barssica sprouts. Food Chem 141:297–303CrossRefGoogle Scholar
  44. Dietrich M, Brown CJ, Block G (2005) The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United States. J Am Coll Nutr 24(4): 266–274. 17PubMedCrossRefPubMedCentralGoogle Scholar
  45. Duggal JK, Singh M, Attri N, Singh PP, Ahmed N, Pahwa S et al (2010) Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease. J Cardiovasc Pharmacol Therapeutics 15(2):158–166PubMedCrossRefPubMedCentralGoogle Scholar
  46. Durrani AI, Schwartz H, Nagl M, Sontag G (2010) Determination of free [alpha]-lipoic acid in foodstuffs by HPLC coupled with CEAD and ESI-MS. Food Chem 120(4):38329–38336CrossRefGoogle Scholar
  47. Dweck AC (2002) Natural ingredients for colouring and styling. International J Cosmetic Sci 24(5):287–302CrossRefGoogle Scholar
  48. El-Sohaimy SA, Elsayed E, El-Saadani HMA (2010) Cloning and in vitro-transcription of chymosin gene in E. coli. Open Nutraceuticals J 3:63–68Google Scholar
  49. Escribano J, Alonso GL, Coca-Prados M, Fernandez JA (1996) Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 100(1–2):22–30Google Scholar
  50. Evans WC (2000) Trease and Evans pharmacognosy, 4th edn. WB Saunders Co, LondonGoogle Scholar
  51. Fenech M (2012) Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity. Mutation Res Fundamental Mol Mech Mutagenesis 733(1–2):21–33CrossRefGoogle Scholar
  52. Flanagan JL, Simmons PA, Vehige J, Willcox MDP, Garrett Q (2010) Role of carnitine in disease. Nutr Metab (Lond) 7:30–44CrossRefGoogle Scholar
  53. Galvano F, Fauci LL, Lazzarino G, Fogliano V, Ritieni A, Ciappellano S et al (2004) Cyanidins: metabolism and biological properties. J Nutr Biochem 15:2–11PubMedCrossRefPubMedCentralGoogle Scholar
  54. de la Garza DRI, Gregory JF, Hanson AD (2007) Folate biofortification of tomato fruit. Proc Natl Acad Sci USA 104:4218–4222Google Scholar
  55. Gerasimenko JV, Flowerdew SE, Voronina SG, Sukhomlin TK, Tepikin AV, Petersen OH et al (2006) Bile acids induce Ca2 + release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. J Biol Chem 281(52):40154–40163PubMedCrossRefPubMedCentralGoogle Scholar
  56. Ghorai S, Banik SP, Verma D, Chowdhury S, Mukherjee S, Khowala S (2009) Fungal biotechnology in food and feed processing. Food Res Int 42:577–587CrossRefGoogle Scholar
  57. Ghosh D (2005) Anthocyanins and anthocyanin-rich extracts in biology and medicine: biochemical, cellular, and medicinal properties. Curr Topics Nutraceutical Res 3(2):113–124Google Scholar
  58. Glier MB, Green TJ, Devlin AM (2014) Methyl nutrients, DNA methylation, and cardiovascular disease. Mol Nutr Food Res 58:172–182PubMedCrossRefPubMedCentralGoogle Scholar
  59. Gossell-Williams M, Fletcher H, McFarlane-Anderson N, Jacob A, Patel J, Zeisel S (2005) Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica. West Ind Med J 54(6):355–359Google Scholar
  60. Gregory SKND (2011) Monogtaph: pantothenic acid. Alternative Med Rev 16(3):263–273Google Scholar
  61. Gropper SS, Smith JL, Groff JL (2009) Advanced nutrition and human metabolism. Wadsworth, Cengage Learning, BelmontGoogle Scholar
  62. Hajirahimkhan A, Dietz B, Bolton J (2013) Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med 79(07):538–553PubMedPubMedCentralCrossRefGoogle Scholar
  63. Hamman JH, Tarirai C (2006) Functional excipients. Chem Today 24:57–62Google Scholar
  64. Hauschild K, Pickr-Freyer KM (2004) Evaluation of a new co-processed compound based on lactose and maize starch for tablet formulation. AAPS Pharm Sci 6(2):27–38CrossRefGoogle Scholar
  65. Herbert V (1979) Pangamic acid (vitamin B15). Am J Clin Nutr 32(7):1534–1540PubMedCrossRefPubMedCentralGoogle Scholar
  66. Herbert V, Herbert R (1981) Pangamate (Vitamin B15), controversies in nutrition. Churchill Livinstone, New York, pp. 159–170Google Scholar
  67. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M (2007) Study on safety and bioavailability of ubiquinol (Kaneka QH™) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 47(1):19–28PubMedCrossRefPubMedCentralGoogle Scholar
  68. Hurrell RF (2003) Influence of vegetable protein sources on trace element and mineral bioavailability. J Nutrit 133(9):2973S–2977SPubMedPubMedCentralGoogle Scholar
  69. Hyvonen P, Suojala L, Orro T, Haaranen J, Simola O, Rontved C, Pyorala SP (2006) Transgenic cows that produce recombinant human lactoferrin in milk are not protected from experimental Escherichia coli intramammary infection. Infect Immun 74:6206–6212PubMedPubMedCentralCrossRefGoogle Scholar
  70. Illium L, Fisher AN, Jabbal GJ, Davis SS (2001) Bioadhesive starch microspheres and absorption enhancing agent’s acts synergistically to enhance the nasal absorption of polypeptides. Int J Pharmacol 222(1):109–119CrossRefGoogle Scholar
  71. Iwasaki M, Inoue M, Otani T, Sasazuki S, Kurashi N, Miura T et al (2008) Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from Japan Public Health Center-base prospective study group. J Clin Oncol 26(10):1677–1683PubMedCrossRefPubMedCentralGoogle Scholar
  72. Jack DB (1995) Keep taking the tomatoes—the exciting world of nutraceuticals. Mol Med Today 1(3):118–121Google Scholar
  73. Jeffrey CP (2009) Alcamo’s fundamentals of microbiology: body systems edition. Jones & Bartlett Learning, Burlington, p 511Google Scholar
  74. Kähkönen MP, Heinonen M (2003) Antioxidant activity of anthocyanins and their aglycons. J Agric Food Chem 51(3):628–633PubMedCrossRefPubMedCentralGoogle Scholar
  75. Kamen B (1997) Folate and antifolate pharmacology. Semin Oncol 24(5 Suppl 18): S18-30–S18-39Google Scholar
  76. Karlic H, Lohninger A (2004) Supplementation of l-carnitine in athletes: does it make sense? Nutrition 20(7–8):709–715PubMedCrossRefPubMedCentralGoogle Scholar
  77. Kimura S, Furukawa Y, Wakasugi J, Ishihar Y, Nakayama A (1980) Antagonism of l(-) pantothenic acid on lipid metabolism in animals. J Nutr Sci Vitaminol (Tokyo) 26(2):113–117CrossRefGoogle Scholar
  78. Klopfenstein TJ, Angel R, Cromwell G, Erickson GE, Fox DG, Parsons C et al (2002) Animal diet modification to decrease the potential for nitrogen and phosphorus pollution. Council Agric Sci Technology 21:175–188Google Scholar
  79. Kowdley KV, Mason JB, Meydani SN, Cornwall S, Grand RJ (1992) Vitamin E deficiency and impaired cellular immunity related to intestinal fat malabsorption. Gastroenterology 102(6):2139–2142PubMedCrossRefPubMedCentralGoogle Scholar
  80. Kramer K, Packer L (2001) R-alpha-lipoic acid. In: Kramer K, Hoppe P, Packer L (eds) Nutraceuticals in health and disease prevention. Marcel Dekker, Inc., New York, pp 129–164Google Scholar
  81. Krutmann J, Humbert P (2010) Nutrition for healthy skin: Strategies for clinical and cosmetic practice. Springer, Berlin, p 153Google Scholar
  82. Kubo H, Fujii K, Kawabe T, Matsumoto S, Kishida H, Hosoe K (2008) Food content of ubiquinol-10 and ubiquinone-10 in the Japanese diet. J Food Compos Anal 21(3):199–210CrossRefGoogle Scholar
  83. Kukuljan M, Vergara L, Stojilkovic SS (1997) Modulation of the kinetics of inositol 1,4,5-trisphosphate-induced [Ca2 +]i oscillations by calcium entry in pituitary gonadotrophs. Biophys J 72(2 Pt 1):698–707PubMedPubMedCentralCrossRefGoogle Scholar
  84. Larner J (2002) D-chiro-inositol—its functional role in insulin action and its deficit in insulin resistance. Int J Experim Diabetes Res 3(1):47–60CrossRefGoogle Scholar
  85. LeBlanc JG, Milani C, De Giori GS, Sesma F, van Sinderen D, Ventura M (2013) Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol 24:160–168PubMedCrossRefPubMedCentralGoogle Scholar
  86. Leermakers ET, Moreira EM, Kiefte-De Jong JC, Darweesh SK, Visser T, Voortman T et al (2015) Effects of choline on health across the life course: a systematic review. Nutr Rev 73(8):500–522PubMedCrossRefPubMedCentralGoogle Scholar
  87. Leonardi R, Zhang YM, Rock CO, Jackowski S (2005) Coenzyme A: back in action. Prog Lipid Res 44(2–3):125–153PubMedCrossRefPubMedCentralGoogle Scholar
  88. Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY (2005) Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemother Pharmacol 55(1):79–90PubMedCrossRefPubMedCentralGoogle Scholar
  89. Lodge JK, Youn HD, Handelman GJ et al (1997) Natural sources of lipoic acid: determination of lipoyllysine released from protease-digested tissues by high performance liquid chromatography incorporating electrochemical detection. J Appl Nutr 49(1 & 2):3–11Google Scholar
  90. Magoulas PL, El-Hattab AW (2012) Systemic primary carnitine deficiency: an overview of clinical manifestations, diagnosis, and management. Orphanet J Rare Diseases 7:68CrossRefGoogle Scholar
  91. Mahan L K, Escott-Stump S (eds) (2000) Krause’s food, nutrition, & diet therapy, 10th edn. W.B. Saunders Company, Philadelphia. ISBN 0-7216-7904-8Google Scholar
  92. Malbasa RV, Loncar ES, Vitas JS, Canadanovic-Brunet JM (2011) Influence of starter cultures on the antioxidant activity of kombucha beverage. Food Chem 127:1727–1731CrossRefGoogle Scholar
  93. Manosroi A, Chutoprapat R, Sato Y, Miyamoto K, Hsueh K, Abe M et al (2011) Antioxidant activities and skin hydration effects of rice bran bioactive compounds entrapped in niosomes. J Nanosci Nanotechnol 11(3):2269–2277PubMedCrossRefGoogle Scholar
  94. Marino BS, Fine KS (2009) Blueprints pediatrics. Lippincott Williams & Wilkins, p 131Google Scholar
  95. Masalha R, Chudakov B, Muhamad M, Rudoy I, Volkov I, Wirguin I (2001) Cobalamin-responsive psychosis as the sole manifestation of vitamin B12 deficiency. Israeli Med Assoc J 3(9):701–703Google Scholar
  96. Matthew D, Boris P, Michael F, Michael S, Athanasios L, de Valérie CL, Andrei O (2002) Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem 277(24):21431–21439CrossRefGoogle Scholar
  97. McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI (2005) Idebenone: a new antioxidant—Part I. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosmet Dermatol 4(1):10–17PubMedCrossRefPubMedCentralGoogle Scholar
  98. McNeil SD (1999) Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance. Plant Physiol 120(4):945–949PubMedPubMedCentralCrossRefGoogle Scholar
  99. Mellors A, Tappel AL (1966a) The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem 241(19):4353–4356PubMedPubMedCentralGoogle Scholar
  100. Mellors A, Tappel AL (1966b) Quinones and quinols as inhibitors of lipid peroxidation. Lipids 1(4):282–284PubMedCrossRefPubMedCentralGoogle Scholar
  101. Miadoková E (2009) Isoflavonoids – an overview of their biological activities and potential health benefits. Interdiscip Toxicol 2(4):211–218PubMedPubMedCentralCrossRefGoogle Scholar
  102. Miadokova E, Masterova I, Vlckova V, Duhova V, Toth J (2002) Antimutagenic potential of homoisoflavonoids from Muscari racemosum. J Ethnopharmacol 18:381–386CrossRefGoogle Scholar
  103. Miller A, Korem M, Almog R, Galboiz Y (2005) Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. J Neurological Sciences 233(1–2):93–97CrossRefGoogle Scholar
  104. Miwa T (1971) Jojoba Oil wax esters and derived fatty acids and alcohols: gas chromatographic analyses. J Am Oil Chem Soc 48(6):259–266CrossRefGoogle Scholar
  105. Monek RV, Builders PF, Kollerg WM, Eneje M, Kunle OO (2012) Physicochemical and binder properties of starch obtained from Cyperus esculentus. Pharm Sci Technol 3(2):379–388CrossRefGoogle Scholar
  106. Moreno DA, Carvaja M, López-Berenguer C, García-Viguera C (2006) Review: chemical and biological characterisation of nutraceutical compounds of broccoli. J Pharmaceutical Biomedical Analysis 41(5):1508–1522CrossRefGoogle Scholar
  107. Naef R (2010) The volatile and semi-volatile constituents of agarwood, the infected heartwood of Aquilaria species: a review. Flavour Fragrance J 26(2):73–87CrossRefGoogle Scholar
  108. Naqvi S, Zhu C, Farre G, Ramessar K, Bassie L, Breitenbach JD et al (2009) Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. Proc Natl Acad Sci USA 106:7762–7767CrossRefGoogle Scholar
  109. Nohynek GJ, Schaefer H (2001) Benefit and risk of organic ultraviolet filters. Regul Toxicol Pharmacol 33(3):285–299PubMedCrossRefGoogle Scholar
  110. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H et al (2006) Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 1770(4):578–584PubMedCrossRefGoogle Scholar
  111. Okamoto T, Matsuya T, Fukunaga Y, Kishi T, Yamagami T (1989) Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res 59(3):288–292PubMedPubMedCentralGoogle Scholar
  112. Oomah BD, Mazza G (2016) Flavonoids and antioxidative activities in buckwheat. J Agric Food Chem 64(25):5197–5206CrossRefGoogle Scholar
  113. Otten JJ, Hellwig JP, Meyers LD (2008) Dietary reference intakes: the essential guide to nutrient requirements. The National Academies Press, WashingtonGoogle Scholar
  114. Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M et al (2006) Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 54(23):8762–8768PubMedCrossRefPubMedCentralGoogle Scholar
  115. Patel AD, Prajapati NK (2012) Review on biochemical importance of Vitamin-U. J Chem Pharm Res 4(1):209–215Google Scholar
  116. Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63:1035–1042PubMedCrossRefPubMedCentralGoogle Scholar
  117. Pifferi G, Santoro P, Pedrani M (1999) Quality and functionality of excipients. IL Farmaco 54:1–14PubMedCrossRefPubMedCentralGoogle Scholar
  118. Prakash R, Gandotra S, Singh LK, Das B, Lakra A (2008) Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy. Gen Hosp Psychiatry 30(6):581–584PubMedCrossRefPubMedCentralGoogle Scholar
  119. Pravst I, Žmitek K, Žmitek J (2010) Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 50(4):269–280PubMedCrossRefPubMedCentralGoogle Scholar
  120. Raddatz G, Bisswanger H (1997) Receptor site and stereospecifity of dihydrolipoamide dehydrogenase for R- and S-lipoamide: a molecular modeling study. J Biotechnol 58(2):89–100PubMedCrossRefPubMedCentralGoogle Scholar
  121. Rahnamaeian M, Vilcinskas A (2015) Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens. Appl Microbiol Biotechnol 99:8847–8855PubMedPubMedCentralCrossRefGoogle Scholar
  122. Rajasekaran A, Sivagnanam G, Xavier R (2008) Nutraceuticals as therapeutic agents: a review. Research J Pharm Tech 1(4):171–174Google Scholar
  123. Rapiejko PJ, Northup JK, Evans T, Brown JE, Malbon CC (1986) G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. Biochem J 240(1):35–40PubMedPubMedCentralCrossRefGoogle Scholar
  124. Reboul E, Richelle M, Perrot E, Desmoulins-Malezet C, Pirisi V, Borel P (2006) Bioaccessibility of carotenoids and vitamin E from their main dietary sources. J Agric Food Chem 54(23):8749–8755PubMedCrossRefPubMedCentralGoogle Scholar
  125. Reljanovic M, Reichel G, Rett K, Lobisch M et al (1999) Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radical Res 31(3):171–179CrossRefGoogle Scholar
  126. Rohr M, Rieger I, Jain A, Schrader A (2011) Influence of repetitive UVA stimulation on skin protection capacity and antioxidant efficacy. Skin Pharmacol Physiol 24(6):300–304PubMedCrossRefPubMedCentralGoogle Scholar
  127. Roig MG, Rivera ZS, Kennedy JF (1995) A model study on rate of degradation of l-ascorbic acid during processing using home-produced juice concentrates. Int J Food Sci Nutr 46(2):107–115PubMedCrossRefPubMedCentralGoogle Scholar
  128. Ryan-Borchers TA, Park JS, Chew BP, McGuire MK, Fournier LR, Beerman KA (2006) Soy isoflavones modulate immune function in healthy postmenopausal women. Am J Clin Nutr 83:118–1125CrossRefGoogle Scholar
  129. Scarpato R, Paganucci L, Bertoli A, Fiore L, Pistelli L, Federico G (2008) Licoflavone C attenuates the genotoxicity of cancer drugs in human peripheral lymphocytes. Phytother Res 22(12):1650–1654PubMedCrossRefPubMedCentralGoogle Scholar
  130. Schagen SK (2017) Review: topical peptide treatments with effective anti-aging results. Cosmetics 4:16–30CrossRefGoogle Scholar
  131. Sebrell WH, Butler RE (1939) Riboflavin deficiency in man (Ariboflavinosis). Public Health Rep 54(48):2121–2131CrossRefGoogle Scholar
  132. Sethi NK, Robilotti E, Sadan Y (2005) Neurological manifestations of vitamin B12 deficiency. Int J Nutri Wellness 2:1–12Google Scholar
  133. Shane B (2000) Folic acid, vitamin B-12, and vitamin B-6. In: Stipanuk M (ed) Biochemical and physiological aspects of human nutrition. W.B. Saunders Co., Philadelphia, pp 483–518Google Scholar
  134. Shay KP, Moreau RF, Smith EJ, Hagen TM (2008) Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life 60(6):362–367CrossRefGoogle Scholar
  135. Shen X, Xiao H, Ranallo R, Wu WH, Wu C (2003) Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299(5603):112–114PubMedCrossRefPubMedCentralGoogle Scholar
  136. Shindo Y, Witt E, Han D, Epstein W, Packer L (1994) Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 102(1):122–124PubMedCrossRefGoogle Scholar
  137. Sibbesen O, Sorensen JF (2010) Polypeptides with xylanase activity. WIPO Patent ApplicationGoogle Scholar
  138. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM (2004) Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr Med Chem 11(9):1135–1146PubMedCrossRefPubMedCentralGoogle Scholar
  139. Smitha RL, Cohenb SM, Doullc J, Ferond VJ, Goodmane JI, Marnettf LJ et al (2005) A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils. Food Chem Toxicol 43(3):345–363CrossRefGoogle Scholar
  140. Spencer JP (2008). Flavonoids: modulators of brain function? British J Nutrition 99:ES 60–77Google Scholar
  141. Steger DJ, Haswell ES, Miller AL, Wente SR, O’Shea EK (2003) Regulation of chromatin remodeling by inositol polyphosphates. Science 299(5603):114–116PubMedCrossRefPubMedCentralGoogle Scholar
  142. Svoboda KP, Deans SG (1995) Biological activities of essential oils from selected aromatic plants. Acta Hort 390:203–209CrossRefGoogle Scholar
  143. Tanphaichitr V (1999) Thiamin. In: Shils ME, Olsen JA, Shike M et al (eds) Modern nutrition in health and disease, 9th edn. Lippincott Williams & Wilkins, Baltimore, p 1999Google Scholar
  144. Theresa LC, James PG (1996) Sexual pharmacology: drugs that affect sexual function. W. W. Norton and Co., New York, p 1996Google Scholar
  145. Traber MG, Atkinson J (2007) Vitamin E, antioxidant and nothing more. Free Radic Biol Med 43(1):4–15PubMedPubMedCentralCrossRefGoogle Scholar
  146. Traber MG, Stevens JF (2011) Free radical biology and medicine—vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med 51(5):1000–1013PubMedPubMedCentralCrossRefGoogle Scholar
  147. Trumbo PR (2006) Pantothenic Acid. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ (eds) Modern nutrition in health and disease, 10th edn. Lippincott Williams & Wilkins, Philadelphia, pp 462–467Google Scholar
  148. Truswell AS (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56:1–14PubMedCrossRefPubMedCentralGoogle Scholar
  149. Tucci M, Benghuzzi H (2003) Structural changes in the kidney associated with ovariectomy and diosgenin replacement therapy in adult female rats. Biomed Sci Instrum 39:341–346PubMedPubMedCentralGoogle Scholar
  150. Van der Put NMJ, Van Straaten HWM, Trijbels FJM, Blom HJ (2001) Folate, homocysteine and neural tube defects: an overview. Experim Biol Med 226(4):243–270CrossRefGoogle Scholar
  151. Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J (2015) Soy and breast cancer: focus on angiogenesis. Int J Mol Sci 16(5):11728–11749PubMedPubMedCentralCrossRefGoogle Scholar
  152. Ververidis F, Trantas E, Douglas C, Vollmer G, Kretzschmar G, Panopoulos N (2007) Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: chemical diversity, impacts on plant biology and human health. Biotech J 2(10):1214–1234PubMedCrossRefPubMedCentralGoogle Scholar
  153. Voet D, Voet JG, Pratt CW (2006) Fundamentals of biochemistry: life at the molecular level, 2nd edn. Wiley, HobokenGoogle Scholar
  154. Wan P, Moat S, Anstey A (2011) Pellagra: A review with emphasis on photosensitivity. The British Journal of Dermatology 164(6):1188–1200PubMedCrossRefPubMedCentralGoogle Scholar
  155. Watanabe F, Yabuta Y, Tanioka Y, Bito T (2013) Biologically active vitamin B12 compounds in foods for preventing deficiency among vegetarians and elderly subjects. J Agric Food Chem 61:6769–6775PubMedCrossRefPubMedCentralGoogle Scholar
  156. Wei P, Liu M, Chen Y, Chen DC (2012) Systematic review of soy isoflavone supplements on osteoporosis in women. Asian Pacific J Tropical Med 5(3):243–248CrossRefGoogle Scholar
  157. White EM (2009) Current status of metabolically engineered resveratrol. MMG 445 Basic Biotechnol 5:84–90Google Scholar
  158. Whitney E, Rolfes SR (2008) Understanding nutrition, 11th edn. Thomson Wadsworth, California, p 154Google Scholar
  159. Whitney E, Sharon RR (2011). Understanding nutrition, 12th edn. Wadsworth, Cengage Learning, California, p 100Google Scholar
  160. WHO (2015) WHO model list of essential medicines (19th List). World Health Organization, April 2015Google Scholar
  161. William DJ, Timothy B, Dirk M (2006) Andrews’ diseases of the skin: clinical dermatology. Elsevier Health Sciences, Amsterdam (10th International edition)Google Scholar
  162. Wu CL, Huang AC, Yang JS, Liao CL, Lu HF, Chou ST et al (2011) Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells. J Orthop Res 29(8):1199–1209PubMedCrossRefPubMedCentralGoogle Scholar
  163. Wu Q, Christensen LA, Legerski RJ, Vasquez KM (2005) Mismatch repair participates in error-free processing of DNA interstrand crosslinks in human cells. EMBO Rep 6(6):551–557PubMedPubMedCentralCrossRefGoogle Scholar
  164. Yamada K (2013) Cobalt: its role in health and disease. In: Sigel A, Sigel H, Sigel RKO (eds) Interrelations between essential metal ions and human diseases. Metal ions in life sciences. Springer, Berlin, pp 295–320Google Scholar
  165. Yang B, Wang J, Tang B, Liu Y, Guo C, Yang P et al (2011) Characterization of bioactive recombinant human lysozyme expressed in milk of cloned transgenic cattle. PLoS ONE 6(3):e17593PubMedPubMedCentralCrossRefGoogle Scholar
  166. Yildiz F (2005) Phytoestrogens in functional foods. Taylor & Francis Ltd., Boca Raton, pp 3–5, 210–211Google Scholar
  167. Zeisel SH, da Costa KA (2009) Choline: an essential nutrient for public health. Nutr Rev 67(11):615–623PubMedPubMedCentralCrossRefGoogle Scholar
  168. Zempleni J, Hassan YI, Wijeratne SS (2008) Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab 3(6):715–724CrossRefGoogle Scholar
  169. Zheng YQ, Liu JX, Wang JN, Xu L (2006) Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 1138:86–94PubMedCrossRefPubMedCentralGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of BotanyChittagong UniversityChittagongBangladesh

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