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Liver Cancers pp 213-223 | Cite as

Oncotherapies for Cholangiocarcinoma

  • Oliver Pickles
  • Yuk Ting Ma
Chapter

Abstract

In this chapter we will consider the evidence behind the use of systemic chemotherapy and/or radiotherapy in biliary tract cancers. Although biliary tract cancers are relatively rare tumours, large-scale randomised clinical trials are feasible with multicentre collaboration and have helped to inform the evidence base. First-line chemotherapy for patients with advanced disease should be with gemcitabine and cisplatin, and the BILCAP study has recently led to a change in practice in the adjuvant setting. Despite these successes, second-line chemotherapy remains unproven, and patients should be enrolled into clinical trials where possible. Emerging and targeted systemic therapy will be discussed in the subsequent chapter.

Keywords

Biliary tract cancer Cholangiocarcinoma Chemotherapy Radiotherapy Chemoradiotherapy ABC-02 BILCAP 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Oliver Pickles
    • 1
  • Yuk Ting Ma
    • 1
  1. 1.Department of Medical OncologyQueen Elizabeth HospitalBirminghamUK

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