Regional Liver-Directed Therapies for Intrahepatic Cholangiocarcinoma

  • Nikitha Murali
  • Lynn Jeanette Savic
  • Nariman Nezami
  • Julius Chapiro
  • Jean-François GeschwindEmail author


Patients with unresectable intrahepatic cholangiocarcinoma (ICC) have a poor prognosis and have historically benefited from very few treatment options. In the last 10 years, image-guided locoregional therapies have been developed to administer targeted treatment to the liver and are increasingly used in primary hepatic malignancies such as ICC. Locoregional therapies primarily consist of ablation and intra-arterial therapies, including conventional transarterial chemoembolization (cTACE), TACE with drug-eluting beads (DEB-TACE), and yttrium-90 radioembolization (Y90-RE). Current clinical evidence suggests that these treatments result in prolonged survival without significantly diminishing patient’s quality of life. This chapter aims to describe each locoregional therapy and the clinical evidence supporting its therapeutic application to unresectable ICC.


Intrahepatic cholangiocarcinoma (ICC) Locoregional therapy Intra-arterial therapy Transarterial chemoembolization cTACE DEB-TACE Y90-RE Radiation Ablation 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Nikitha Murali
    • 1
  • Lynn Jeanette Savic
    • 1
    • 2
  • Nariman Nezami
    • 1
    • 3
  • Julius Chapiro
    • 1
    • 3
  • Jean-François Geschwind
    • 4
    Email author
  1. 1.Department of Diagnostic RadiologyYale University School of MedicineNew HavenUSA
  2. 2.Department of Radiology and Biomedical ImagingYale School of MedicineNew HavenUSA
  3. 3.Department of Radiology and Biomedical ImagingYale New Haven Hospital, Yale School of MedicineNew HavenUSA
  4. 4.PreScience Labs LLCWestportUSA

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