Current and Emerging Medical Therapies for Advanced Disease in Intrahepatic Cholangiocarcinoma

  • Aileen Deng
  • Steven CohenEmail author


Biliary tract cancers are rare cancers with traditionally dismal clinical outcomes. Systemic chemotherapy remains the mainstay of treatment for patients with advanced disease. Combination therapy with cisplatin and gemcitabine is the current standard of care. Recent advancements in genomic profiling and next-generation sequencing technologies have led to a growing understanding of the true heterogeneity within this disease. Large mutational profiling studies have identified key genomic differences among intrahepatic and extrahepatic cholangiocarcinoma and gallbladder carcinoma. Understanding these genomic alterations and identifying targetable mutations will be critical to developing effective biomarker and targeted therapy options. In this chapter, we will review current and emerging systemic treatment options for cholangiocarcinoma.


Cholangiocarcinoma Biliary tract cancer Gallbladder cancer Chemotherapy Targeted therapy Immunotherapy Genomic alteration Genomic profiling 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Sidney Kimmel Cancer CenterThomas Jefferson University HospitalhPhiladelphiaUSA
  2. 2.Rosenfeld Cancer Center at Abington Jefferson HealthAbingtonUSA
  3. 3.Department of Medical Oncology, Sidney Kimmel Cancer CenterThomas Jefferson University HospitalPhiladelphiaUSA

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