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Comparative Physiology

  • Nicolaas Westerhof
  • Nikolaos Stergiopulos
  • Mark I. M. Noble
  • Berend E. Westerhof
Chapter

Abstract

To compare parameters in different mammals we make use of the so-called allometric equation: PA = PA0 Me, with PA the parameter of interest, PA0 a reference value, M body mass, and e the exponent. The RpC-time of aortic pressure decay in diastole, and heart period, Tperiod, both scale as M1/4, their ratio thus being independent of body mass and thus similar in mammals. Volume parameters such a heart size and Stroke Volume, SV, are proportional to body mass. Since CO equals HR times SV, CO is proportional to M3/4. Basal metabolism is proportional to CO, and thus also proportional to M3/4. The coupling parameters (Chap. 14 and 31) are independent of body mass. The ratio of peripheral resistance and aortic characteristic impedance is also independent of animal size, implying that normalized aortic input impedance is similar in mammals. These mass-independent relations imply that wave shapes of pressure and flow are similar, pressures equal, but CO=CO0M3/4 and Basal Metabolism, BMr=BMr0M3/4, depend on body mass. The quantitative similarity of pressures in mammals suggest that even borderline hypertension is abnormal.

Keywords

Allometry Coupling parameters Pressure Stroke Volume Cardiac Output Heart Rate 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Nicolaas Westerhof
    • 1
  • Nikolaos Stergiopulos
    • 2
  • Mark I. M. Noble
    • 3
  • Berend E. Westerhof
    • 1
  1. 1.Department of Pulmonary Diseases, Amsterdam Cardiovascular SciencesVU University Medical CenterAmsterdamThe Netherlands
  2. 2.Laboratory of Hemodynamics and Cardiovascular TechnologyEcole Polytechnique Fédérale de Lausanne (EPFL), Institute of BioengineeringLausanneSwitzerland
  3. 3.Cardiovascular Medicine, Department of Medicine and TherapeuticsUniversity of AberdeenAberdeenUnited Kingdom

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