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Good’s Syndrome (GS): Thymoma with Immunodeficiency

  • Hans-Hartmut PeterEmail author
Chapter
Part of the Rare Diseases of the Immune System book series (RDIS)

Abstract

The association in adults of thymoma with hypogammaglobulinemia, low B-cell counts, and a variable degree of cellular immunodeficiency (low CD4 and NK cells) was first described by R.A. Good as a rare form of acquired combined immunodeficiency. Besides an increased susceptibility to respiratory infections with encapsulated bacteria, many patients suffer from chronic diarrhea, opportunistic infections (e.g., CMV, candida, tuberculosis, Pneumocystis), pure red cell aplasia (PRCA), and various autoimmune diseases notably myasthenia gravis (MG).

Keywords

Combined immunodeficiency Thymoma Hypogammaglobulinemia Respiratory and gastrointestinal infections Pure red cell aplasia Autoimmunity Myasthenia gravis 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Center for Chronic ImmunodeficiencyUniversity Medical Center FreiburgFreiburgGermany

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