Fabrication of PLA-HAp-CS Based Biocompatible and Biodegradable Feedstock Filament Using Twin Screw Extrusion
In this chapter, detailed procedure for development of biocompatible and biodegradable composite material based feedstock filament, by using twin screw extrusion (TSE) process has been highlighted. The poly lactic acid (PLA) has been selected as a polymer matrix with hydroxyapatite (HAp) and chitosan (CS) as osteo-conductive filler for potential use in medical applications. The feedstock filament of PLA-HAp-CS can be used in fused deposition modelling (FDM) open source 3D printer (without change in any hardware or software of system) for printing of functional/ non functional prototypes. The results are supported by tensile testing; thermal analysis; and scanning electron microscope (SEM) based photomicrographs. Finally the feasibility of fabrication of functional prototypes for medical applications by using in house prepared feedstock filament on the FDM has been ascertained.
KeywordsFused deposition modelling CS HAp PLA Biomedical implants Biocompatibility Biodegradability Wear
The authors are thankful to SERB (DST), GOI for financial support and Manufacturing Research Lab (Dept. of Production Engineering, Guru Nanak Dev Engineering College, Ludhiana), Punjabi University Patiala for technical support.
- 3.Choudhury, A., Chakraborty, D. and Reddy, B. (2007), “Extruder path generation for Curved Layer Fused Deposition Modeling”, Computer-aided design Journal, Vol. 40, pp. 235–243.Google Scholar
- 5.Kumar, R., Singh, R., Hui, D., Feo, L. and Fraternali, F. (2017), “Graphene as biomedical sensing element: State of art review and potential engineering applications”, Composites Part B: Engineering, https://doi.org/10.1016/j.compositesb.2017.09.049
- 8.Sasso, R. C., Williams, J. I., Dimasi, N., Meyer Jr. P. R. (1998), “Postoperative drains at the donor site of iliac-crest bone grafts. A prospective, randomized study of morbidity at the donor site in patients who had a traumatic injury of the spine”, J Bone Joint Surgical Am, Vol. 80, pp. 631–635.CrossRefGoogle Scholar
- 21.Sarasam, A. and Madihally, S. V. (2005), “Characterization of chitosan-polycaprolactone blends for tissue engineering applications”, Biomaterials, Vol. 26, Issue 5, pp. 500–508.Google Scholar
- 26.Yin, Y. J., Zhao, F., Song, X. F., Yao, K. D., Lu, W. W. and Leong, J. C. (2000), “Preparation and characterization of hydroxyapatite/chitosan–gelatin network composite”, J ApplPolymSci, Vol. 77, pp. 2929–2938.Google Scholar
- 37.Singh, R., Kumar, R., Ranjan, N., Penna, R. and Fraternali, F. (2017), “On the recyclability of polyamide for sustainable composite structures in civil engineering”, Composite Structures, https://doi.org/10.1016/j.compstruct.2017.10.036
- 41.Guo, L., Huang, M. and Zhang, X.(2003),“Effects of sintering temperature on structure of hydroxyapatite studied with Rietveld method”, Journal of Materials Science: Material in Medicine, Vol. 14, Issue 9, pp. 817–822.Google Scholar