New Daily Persistent Headache

  • Lauren R. NatbonyEmail author
  • Huma U. Sheikh
  • Mark W. Green


New daily persistent headache (NDPH) is a unique form of chronic daily headache. The distinguishing feature of NDPH is a headache that starts abruptly, and patients can often recall the exact day of headache onset. Clinically, NPDH lacks characteristic features and may resemble migraine or tension-type headache. Diagnosis relies on first eliminating secondary mimics. Several different classes of medications have been used for treatment of NDPH with varying results. In clinical practice, treatment is often chosen based on the headache phenotype. However, most therapies are ineffective or minimally effective thereby making NDPH one of the most refractory types of headache to treat.


New daily persistent headache Headache Chronic daily headache 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Lauren R. Natbony
    • 1
    Email author
  • Huma U. Sheikh
    • 2
  • Mark W. Green
    • 3
    • 4
    • 5
  1. 1.Neurology, Center for Headache and Facial PainIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.NeurologyMount SinaiNew YorkUSA
  3. 3.NeurologyIcahn School of Medicine at Mt. SinaiNew YorkUSA
  4. 4.AnesthesiologyIcahn School of Medicine at Mt. SinaiNew YorkUSA
  5. 5.Rehabilitation MedicineIcahn School of Medicine at Mt. SinaiNew YorkUSA

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