Structural Biology of Auxin Signal Transduction
The phytohormone auxin is a central regulator of plant growth and development and is required for response to multiple environmental and developmental cues. Primary auxin response is mediated by several protein families, including members of the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX PROTEIN (TIR1/AFB) family of F-box proteins, the AUXIN RESPONSE FACTOR (ARF) family of transcription factors, and the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of repressor proteins. Structures of multiple domains of each of these protein families have revealed molecular insight into auxin signal transduction. Here, we provide an overview of the structural details of auxin signaling revealed by these studies and explore questions and models suggested by these structural data.
- Dinesh DC, Kovermann M, Gopalswamy M, Hellmuth A, Calderon Villalobos LI, Lilie H, Balbach J, Abel S (2015) Solution structure of the PsIAA4 oligomerization domain reveals interaction modes for transcription factors in early auxin response. Proc Natl Acad Sci U S A 112:6230–6235CrossRefPubMedPubMedCentralGoogle Scholar
- Ruegger M, Dewey E, Hobbie L, Brown D, Bernasconi P, Turner J, Muday G, Estelle M (1997) Reduced naphthylphthalamic acid binding in the tir3 mutant of Arabidopsis is associated with a reduction in polar auxin transport and diverse morphological defects. Plant Cell 9:745–757CrossRefPubMedPubMedCentralGoogle Scholar
- Tatematsu K, Kumagai S, Muto H, Sato A, Watahiki MK, Harper RM, Liscum E, Yamamoto KT (2004) MASSUGU2 encodes Aux/IAA19, an auxin-regulated protein that functions together with the transcriptional activator NPH4/ARF7 to regulate differential growth responses of hypocotyl and formation of lateral roots in Arabidopsis thaliana. Plant Cell 16:379–393CrossRefPubMedPubMedCentralGoogle Scholar