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Physical Properties Characterization

  • Anthony J. Hickey
  • Stefano Giovagnoli
Chapter
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)

Abstract

Powder characterization is a fundamental step for proper design and control of solid dosage form manufacturing processes. Properties like surface area, charge, crystal habit, the presence of water and impurities are responsible for dramatic changes in the physical-chemical and biological behavior of pharmaceutical products. Therefore, accurate tuning of powder features is compulsory. In this regard, an arsenal of particle characterization techniques have today reached a high level of reliability and sensitivity, which allow insightful investigation of the complex crosstalk between particle properties and pharmaceutical processes. Novel technologies are now on the verge of breakthrough advances thanks to new methodologies and computer science.

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Anthony J. Hickey
    • 1
  • Stefano Giovagnoli
    • 2
  1. 1.Discovery Science and TechnologyRTI InternationalResearch Triangle ParkUSA
  2. 2.Department of Pharmaceutical SciencesUniversity of PerugiaPerugiaItaly

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