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Solid-State Chemistry

  • Anthony J. Hickey
  • Stefano Giovagnoli
Chapter
Part of the AAPS Introductions in the Pharmaceutical Sciences book series (AAPSINSTR)

Abstract

The compositional and structural characteristics of the solid represent the spatial physicochemical factors with implications for potential temporal chemical and physical effects. Characterizing these properties may be used to establish the initial and final state of a solid with respect to a process which may be connected to product quality and performance. These properties partially define expectations of stability, dissolution, and bioavailability, which in turn relate to safety and efficacy.

Occasionally particles exist with disordered, amorphous, molecular structure. Most frequently ordered systems exist that are defined by uniform distances between adjacent molecules that define the general morphology of the crystal system. However, the particle appearance may vary based on constraints of crystal growth or the presence of impurities.

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Copyright information

© American Association of Pharmaceutical Scientists 2018

Authors and Affiliations

  • Anthony J. Hickey
    • 1
  • Stefano Giovagnoli
    • 2
  1. 1.Discovery Science and TechnologyRTI InternationalResearch Triangle ParkUSA
  2. 2.Department of Pharmaceutical SciencesUniversity of PerugiaPerugiaItaly

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