Pretransplant Considerations in Patients with Obstructive Lung Disease: COPD, Lymphangioleiomyomatosis, Cystic Fibrosis, and Non-CF Bronchiectasis

  • Shahnaz Ajani
  • Robert M. Kotloff


Pulmonary diseases characterized by progressive and irreversible airflow obstruction include chronic obstructive pulmonary disease (COPD), lymphangioleiomyomatosis (LAM), cystic fibrosis (CF), and non-CF bronchiectasis. Despite advances in treatment of these diseases, all have the potential to progress to a far-advanced and life-threatening stage, prompting consideration of lung transplantation as a therapeutic option. Although considerable experience has been accrued in transplanting these patient populations, questions remain about the appropriate time to list patients, the true survival benefits of transplantation, and in the case of COPD and LAM, the best procedure to perform. This chapter will explore the available literature with the goal of offering an evidence- and/or consensus-based assessment of issues related to the pretransplant evaluation and management of patients with obstructive lung disorders.


Chronic obstructive pulmonary disease Lymphangioleiomyomatosis Cystic fibrosis Bronchiectasis Lung transplantation Lung allocation score 


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Copyright information

© The Author(s) 2018

Authors and Affiliations

  1. 1.Division of Pulmonary, Allergy, Critical Care, and Sleep MedicineEmory University Hospital, Emory University School of Medicine, Emory Transplant CenterAtlantaUSA
  2. 2.Department of Pulmonary MedicineCleveland ClinicClevelandUSA

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