Identification of the Core Neural Network Subserving PTSD in Animal Models and Their Modulation

  • Maxwell Bennett
  • Jim Lagopoulos


It is not possible to develop a full animal model of PTSD, given the human elements required to be satisfied according to DSM-IV, such as the traumatic event which should be accompanied by ‘intense fear, helplessness or horror’. It is, however, possible to interpret the behaviour of animals in these terms without of course knowing that such interpretations are correct rather than being simply anthropomorphic. DSM-IV sets out six sets of criteria (listed A to F) that must be met before a diagnosis of PTSD can be specified for a patient. Within each of these sets, it is possible to discern behaviours that might be interpreted across mammalian species, so allowing the possibility of developing animal models of PTSD. Such diagnostic criteria for PTSD are the following, taken from DSM-IV (American Psychiatric Association 1994; Table 309.81; following their numbering):


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Maxwell Bennett
    • 1
  • Jim Lagopoulos
    • 2
  1. 1.The University of SydneyBrain and Mind CentreCamperdown NSWAustralia
  2. 2.Sunshine Coast Mind and Neuroscience Thompson InstituteUniversity of Sunshine CoastBirtinyaAustralia

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