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T1 Mapping in Stem Cell Therapy

  • Yoko Kato
  • Mohammad R. Ostovaneh
  • Bharath Ambale-Venkatesh
  • Joao Lima
Chapter

Abstract

Cell therapy is increasingly seen as a viable technique to recover myocardial function by reverse remodeling. The goal of cell therapy is the functional recovery of the heart and consequently prognostic improvement, but the results of prior research has been inconsistent and controversial. Basic science experiments have also shown that cell therapy may improve myocardial function by reducing myocardial fibrosis and promoting the growth of active myocytes. From the aspect of imaging, late gadolinium enhancement imaging alone may not be sufficient to identify the effects of cell therapy. T1 mapping with its’ increased sensitivity to detect diffuse interstitial fibrosis may be seen as a viable and attractive endpoint, particularly, as it pertains to subtle changes in the structure of the underlying extracellular matrix. T1 mapping has also shown prognostic value in studies in participants with non-ischemic cardiomyopathy. The rationale to use T1 mapping in stem cell therapy exists on its utility to assess current disease status, as well as the assessment of future prognosis.

Keywords

T1 mapping Stem cell therapy Ischemic heart disease Nonischemic cardiomyopathy Late gadolinium enhancement (LGE) Cardiac MRI Cellular cardiomyoplasty Myocardial scar Extracellular volume (ECV) 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Yoko Kato
    • 1
  • Mohammad R. Ostovaneh
    • 1
  • Bharath Ambale-Venkatesh
    • 2
  • Joao Lima
    • 1
    • 2
  1. 1.Department of CardiologyJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of RadiologyJohns Hopkins University School of MedicineBaltimoreUSA

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